e.hormone

General Information

Convening 20 years after the first Estrogens in the Environment meeting, the symposium mingled historical perspectives, topic reviews, and latebreaking research into sessions covering hormonal signaling, chemicals as hormones, hormone response mechanisms, developmental toxicology, and future directions. Below are summaries of select presentations.

Contact
Center for Bioenvironmental Research
at Tulane and Xavier Universities
1430 Tulane Avenue, SL-3
New Orleans, LA 70112-2699
e.hormone@tulane.edu



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Poster Abstracts

1. Uterine Response To Estradiol: Low-dose Facilitation And High-dose Inhibition Due To Fetal Exposure to Diethylstilbestrol And Methoxychlor In CD-1 Mice.
LC Alworth, KL Howdeshell, RL Ruhlen, FS vom Saal,Division of Biological Sciences, University of Missouri, Columbia, MO 65211

2. Expression Of AUF1/hnRNP D, A Regulator Of mRNA Degradation, Is Controlled By Estrogen In Rat Uterus.
Y. Arao 1,2, A. Kikuchi 1,2, and F. Kayama 1,2;1, Jichi Medical School, Tochigi, Japan, 2, CREST, JST, Japan

3. Soybean Phytoestrogens: Quantitation And The Accumulation Of Isoflavonoid Phytoalexins.
Stephen M. Boue, Carol H. Carter, Kenneth C. Ehrlich and Thomas E. Cleveland,Southern Regional Research Center, USDA, New Orleans, LA 70124

4. Phytochemical Glyceollins, Isolated From Soy, Mediate Anti-Hormonal Effects Through Estrogen Receptor Alpha And Beta
Matthew E. Burow, Steve Boue, Bridgette M. Collins-Burow, Lilia I. Melnik, Bich N. Duong, Tom Weiss, Ed Cleavland, John A. McLachlan.
Environmental Endocrinology Project at the Tulane-Xavier Center for Bioenvironmental Research
Molecular and Cellular Biology Program, Department of Pharmacology, Tulane University Medical Center
Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine
School of Pharmacy at Xavier University
The Southern Research Center, United States Department of Agriculture, New Orleans, Louisiana 70112

5. Immunohistochemical Detection Of Vitellogenin (Vg) In Formalin-Fixed Livers Of Lepomis macrochirus.
Burse, Jeanine R.¹, Ann O. Cheek², and Henry L. Bert Jr.¹.
¹Ecology, Evolution, and Organismal Biology Dept., Tulane University, New Orleans, LA 70118 and
²Dept. of Biology, Southeastern University of Louisiana, Hammond, LA 70402

6. In Vivo Effects of Cadmium on the Estrogen Signaling Pathway During Spermatogenesis.
Gloria V. Callard*, Chunhua Wang, Roshana Sikora, and Marlies Betka
Department of Biology, Boston University, Boston MA 02215

7. Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development (thelarche)
Ivelisse Colón¹, Doris Caro¹, Osvaldo Rosario¹, Carlos J. Bourdony
¹Department of Chemistry, University of Puerto Rico, San Juan, Puerto and
² Premature Sexual Development Registry of Puerto Rico, Department of Health Pediatric Endocrinology Division, San Juan City Hospital, Puerto Rico Department of Pediatrics, University of Puerto Rico, School of Medicine

8. A cDNA From The Fresh Water Mussel (Elliptio complanata) With Homology To Vertebrate Steroid Receptors.
Noemi Custodia, Seung Jae Won, and Ian P. Callard
Department of Biology, Boston University, Boston, MA 02215

9. Biomarkers For Exposure to Environmental Estrogens.
W. Dean-Colomb¹ and E. Jeffery².
¹Dept of Veterinary Biosciences and ²Dept of Food Science and Human Nutrition. University of Illinois, Urbana-Champaign.

10. Phytoestrogen Signaling: Insights From Plant/Bacteria Symbiosis.
Fox, J., Kow, K., Burow, M., Starcevic, M., McLachlan, J.
Molecular and Cellular Biology Program and Environmental Endocrinology Project at the Tulane-Xavier Center for Bioenvironmental Research, New Orleans LA 70112

11. Bisphenol A Is Released From Used Polycarbonate Rodent Cages.
KL Howdeshell, PH Peterman, RL Ruhlen, BM Judy, WV Welshons and FS vom Saal,
University of Missouri and Columbia Environmental Research Center (USGS), Columbia, MO 65211

12. Estrogenic Effects Of Bisphenol A In Mice Following In Utero And Post-natal Exposure.
Caroline Markey, Cheryl Michaelson, Electra Veson, Carlos Sonnenschein & Ana Soto,
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston MA 02111-1800.

13. Dietary Estrogens Interactions With The Estrogen Receptor And Their Efeect On The Estrogen Receptor Signaling Pathways
Georgi N. Nikov¹, Nancy E. Hopkins*², Stephen Boue³and William L. Alworth*¹¹ Tulane University, New Orleans, LA 70118,USA
² Millsaps College, Jackson, MS 39210, USA
³ Southern Regional Research Center, U.S.D.A., New Orleans, LA 70124, USA

14. Applications Of In Vivo Tests For Estrogen Effects In The Reed Frog Hyperolius Argus.
N.C. Noriega* and T.B. Hayes.
University of California, Berkeley.

15. Aromatase Activity In The Ovary Of Mosquitofish Gambusia Holbrooki, Collected From The Fenholloway And Econfina Rivers, Florida.
Edward F. Orlando¹, William P. Davis², Lisa Catabiano¹, Danielle Bass¹,and Louis J. Guillette, Jr.¹¹Department of Zoology, University of Florida, Gainesville 32611
Tele: 352+392-1098, Email: efo@zoo.ufl.edu
²EPA – Gulf Ecology Division, 1 Sabine Island Drive, Gulf Breeze, Florida 32561

16. The Regulation of Barbiturate-mediated Induction of CYP 102 by Xeno- and Phytoestrogens : Possible intersection of signalling pathways in primitive systems.
Rajendram V Rajnarayanan, Christopher W Rowley and William L Alworth
Department of Chemistry , Tulane University, New Orleans 70118
and Tulane / Xavier Center for Bioenvironmental Research, New Orleans, LA 70112

17. Fetal Exposure To Very Low Doses Of Ethinyl Estradiol Increases Prostate Size And Androgen Receptors In CF-1 And CD-1 Mice.
RL Ruhlen, KA Thayer, DE Preziosi, KL Howdeshell, WV Welshons, FS vom Saal,
University of Missouri (Columbia), Columbia MO 65211

18. A Low Dose Effect Of Environmental Endocrine Disruptors On Female Mouse Thymus, With Special Reference To T Cell Apoptosis.
Kou Sakabe, Fujio Kayama, Takahiko Yoshida, Hiroyuki Aikawa
Department of Morphology, Tokai University School of Medicine, Isehara, Kanagawa, JapanÅiKS)
Department of Environmental Health, Jichi Medical School, Kawachi, Tochigi, JapanÅiFK)
Department of Environmental Health, Tokai University School of Medicine, Isehara, Kanagawa, JapanÅiTY & HA)

19. Vitellogenin As A Biomarker For Estrogenic Chemicals: Develoment Of Antibodies And Primers With Broad Species Applications
.Kyle Selcer, Phil Foret, Jodi Danyo, Danielle Wagner and Brent Palmer
Department of Biological Sciences, Duquesne University, Pittsburgh, PA and Department of Biology, University of Kentucky, Lexington, KY.

20. Bisphenol A Bioaccumulates In The Serum Of Pregnant Mice.
Julia A. Taylor*, Barbara M. Judy*, Brian A. Rottinghaus*, Kellee J. Blackwell*, George E. Rottinghaus*, Leanne C. Alworth**, Frederick S. vom Saal** and Wade V. Welshons*
*Department of Veterinary Biomedical Sciences and **Division of Biological Sciences, University of Missouri-Columbia, Columbia, MO 65211-5120.21.

Environmental Estrogens and Breast Cancer Therapeutics: Characterization Of The Diverse Ligand Binding Properties Of The Estrogen Receptor.
Dana E. Warn and Deborah S. Wuttke,
Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309-0215, USA.

22. Gonadal Development In The Japanese Medaka (Oryzias latipes) As A Model For Estrogenic Potency Determination.
Mingyi Wen,¹² Arunthavarani Thiyagarajah, A.,¹² Mary B. Anderson,³ and William R. Hartley¹²¹Department of Environmental Health Sciences, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.
² Center for Bioenvironmental Research, Tulane and Xavier University, New Orleans, LA.
³Department of Anatomy, School of Medicine, Tulane University Medical Center, New Orleans, LA.

23. Aroclor 1242 Alters Aromatase Activity During Embryogenesis In The Red-Eared Slider Turtle, A Species With Temperature-Dependent Sex Determination.
Emily Willingham and David Crews,
Institute of Reproductive Biology, The University of Texas at Austin, Austin, TX, 78712

24. Organochlorine Compounds And Menstrual Cycle Function.
Gayle C. Windham, Diana Lee, Gina Margillo, Kirsten Waller, Shanna Swan, Bill Lasley
California Department of Health Services, Univeristy of California, Davis and University of Missouri

25. Yolk Protein Synthesis In Caenorhabditis elegans: Potential Regulation By Estrogens?
Seung-Jae Won, Mark Wieland, Chris Li, and Ian P. Callard
Department of Biology, Boston University, Boston, MA 02215

Conference Program

Session I. Hormonal Signals and Networks in the Environment

Chair: David Crews, Department of Zoology, University of Texas.

Symposium Address ( playable by QuickTime, RealPlayer, or any MP3 player)
Roy Hertz, Scientist Emeritus, National Institute of Health, "Hormonal Approaches to HIV Treatment Arriving from the Protection Factor of Pregnancy".

Plenary Lecture, John McLachlan, Center for Bioenvironmental Research, Tulane and Xavier Universities, "Environmental Hormones: How We Got Here from There".

W. Mike Howell, Department of Biology, Samford University, "Environmental Formation of Androgens and Fish Masculinization".

Ann Cheek, Department of Biological Sciences, Southeastern Louisiana University, "Thyroid Hormone Activity of Environmental Chemicals and Biological Consequences in Aquatic Vertebrates".

Michael Baker, Department of Molecular Biology, University of California at San Diego, "Evolution of the Steroid Hormone Response System".

Koji Arizono, Faculty of Environmental Symbiotic Sciences, Prefectural University of Kumamoto, "The Screening of Environmental Estrogens using the worm, c.elegans".

Shannon Atkinson, Marine Biology Institute, University of Hawaii, "Estrogens in Coral Reef Environments".

Session II. Hormones as Chemicals, Chemicals as Hormones

Chair: Manfred Metzler, Institute of Food Chemistry, Karlsruhe University.

Plenary Lecture, John Katzenellenbogen, Department of Chemistry, University of Illinois, "Estrogenic Chemicals: Twenty Years of Structural Biology".

William Toscano, Department of Environmental Health Sciences, University of Minnesota School of Public Health, "Dioxin and Estrogen Receptor Systems: Problems in Molecular Repartee?"

Larry Needham, National Center for Environmental Health, Center for Disease Control and Prevention, "Human Health Outcomes Related to Dioxin Exposure".

Takeki Tatsui, Department of Pharmacology, The Nippon Dental Institute, "Genetic activity of estrogens in-vitro".

Charles L. McKenney, Jr., National Health & Environmental Effects Research Laboratory, USEPA Gulf Breeze FL., "Reproductive and Developmental Responses of Estuarine Crustaceans to Insect Juvenile Hormone Analogs".

Warren Foster, Center for Women's Health, Cedars-Sinai Medical Center, "Detection of Endocrine Disrupting Chenicals and Dietary Factors in Samples of Second Trimester Human Amniotic Fluid".

Irva Hertz-Picciotto, Department of Epidemiology, University of North Carolina, "In Utero Exposures to Organochlorines and Child Development in a Birth Cohort from the 1960's".

Session III. Mechanisms of Hormone Responses

Chair: Anna Soto, Department of Cell Biology, Tufts University.

Plenary Lecture, Kenneth Korach, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, "From One to Two to None: Two Dynamic Decades for the Estrogen Receptor".

John Ashby, Central Toxicology Laboratory, Zeneca Pharmaceuticals, "The Promiscuous Receptor for Estrogen as Seen from Phytoestrogens".

Bruce Blumberg, Department of Developmental and Cell Biology, University of California, Irvine, "SXR, A Nuclear Receptor Activated by Steroids and Xenophobic Toxicants".

Michael Fry, Center for Avian Biology, University of California-Davis, "Developmental Disruption of Brain Development and Reproduction Behavior of Birds".

Jimmy Spearow, Section of Neurobiology, Physiology, and Behavior, University of California-Davis, "Genetic Variation in Susceptibility to Endocrine Disruption by Estrogen".

Steven Hill, Department of Anatomy, Tulane University Medical Center, "Melatonin-Estrogen Cross Talk, or How Our Brain Talks to Our Body".

Session IV. Developmental Toxicology of Hormonally Active Chemicals.

Chair: Retha Newbold, Laboratory of Toxicology, National Institute of Environmental Health Sciences.

Session Introduction, Retha Newbold, Laboratory of Toxicology, National Institute of Environmental Health Sciences.

Plenary Lecture, Taisen Iguchi, Department of Biology, Yokohama University, "Mechanisms of Developmental Toxicity of Environmental Estrogens in Mammals".

Liang Ma, Department of Cell Biology, Harvard University, "Diethylstilbestrol and the Hox Gene Complex in Mouse Genital Tract Development".

Risto Santti, Institute of Biomedicine, University of Turku, "Urethral Dyssynergia: An Estrogen-Related Developmental Condition?"

Susan Jobling, Department of Biological Sciences, Brunel University, UK, "Unraveling the Causes and Consequences of Intersexuality in Wild Fish".

David M. Gardiner, Department of Developmental and Cell Biology, University of California-Irvine, "Frog Deformities: Role of Endocrine Disruptors During Amphibian Development".

Tyrone Hayes, Department of Inegrative Biology, University of California-Berkeley, "Comparative Endocrinology of Amphibians".

James Burkhart, Laboratory of Toxicology, National Institute of Environmental Health Sciences, "Hormonal Influences Associated with Amphibian Malformation and Decline".

Session V. Focus on Environmental Hormones: Where do We Go from Here?

Chair: Valerie P. Wilson, Center for Bioenvironmental Research, Tulane and Xavier Universities.

Session Introduction, Valerie P. Wilson, Center for Bioenvironmental Research, Tulane and Xavier Universities.

Lou Guillette, Department of Biology, University of Florida, "Ecosystem Response to Hormones in the Environment: What are the Long-Term Consequences?"

Shanna Swan, Family and Community Medicine, University of Missouri, "Assessing the Impact of Environmental Hormones on Human Reproduction: Is a New Paradigm Required for Epidemiology?"

Claude Hughes, Center for Women’s Health, Cedars Sinai Medical Center, UCLA School of Medicine and 1999 Greater New Orleans Foundation Distinguished Lecturer on the Environment and Women's Health, "Women's Health as Seen Through the Prism of Environmental Estrogens".

Summary Remarks, John A. McLachlan, Center for Bioenvironmental Research, Tulane and Xavier Universities.

Lindsey Berkson, Author and Visiting Scholar, "One Woman Exposed: A Life of Hormone Disruption".

Margaret Lee Braun, Author and Producer, Presentation and Viewing of Art Exhibit, "Exposed: The Untold Story of DES".