Signal Transduction Lab
Tulane University
1430 Tulane Avenue
New Orleans, Louisiana 70112
Ceramide
Signaling in MCF7 Cell
Hep3B
Cells with GFP-PKC Alpha Treated with PMA
Pro-and anti-apoptotic
pathways. The death receptor ligands, such as TNF and
TRAIL, initiate pro-apoptotic pathways, such as sphingomyelinase
activation, leading to ceramide and cytochrome c release
from mitochondria. In addition, caspase 8 and NF-kB can
be concurrently activated leading to simultaneous stimulation
of both apoptotic and anti-apoptotic signals. The relative
constitutive expression of anti-apoptotic pathways such
as PI3K, PKC and the MAPKs influences the efficacy of
pro-apoptotic signals.
