Barbara Beckman, Ph.D. Director Molecular and Cellular Biology Program Tulane University Professor Department of Pharmacology Tulane University 1430 Tulane Avenue New Orleans, Louisiana 70112 bbeckman@tulane.edu For over 25 years, my laboratory has investigated signal transduction mechanisms critical to cancer cell survival in response to hypoxic and therapeutic agents. Using hepatocellular carcinomic cells as well as breast cancer cell lines, we have elucidated the roles of a number of protein kinases in cell survival, proliferation, and differentiation. Recent studies have addressed mechanisms of cell survival in response to environmental stresses such as hypoxic and inflammatory cytokines. The goal is to establish cell context-specific signaling pathways that are amenable to therapeutic manipulation.     Barbara Beckman's CV download a PDF document of this CV   CBR Signal Transduction Lab Papers from 2000 to present   Godin DA, Fitzpatrick PC, Scandurro B, Belafsky PC, Woodard BA, Amedee RG, Beech DJ, Beckman BS. PH-20: A novel tumor marker for laryngeal cancer. Arch Otolarnygol - Head Neck Surg 126:402- 404, 2000 Burow ME, Collins-Burow BM, Weldon CB, Lippel A, McLachlan JA, Clejan S, Beckman BS. Cross-talk between phosphatidylinositol 3-kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions. J Biol Chem 275:9628-9635, 2000 Burow ME, Weldon CB, Chiang T-C, Tang Y, Collins-Burow BM, Rolfe K, Li S, McLachlan JA, Beckman BS. Differences in protein kinase C and estrogen receptor a, b expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants. Int J Oncol 16:1179-1187, 2000 Burow ME, Weldon CB, Melnik LI, Duong BN, Collins-Burow BM, Beckman BS, McLachlan JA. PI3/K/AKT regulation of NF-kB signaling events in suppression of TNF-induced apoptosis. Biochem BiophysRes Commun 271:342-345, 2000 Scandurro AB, Weldon CB, Gutierrez YG, Alam J, Beckman BS. Gene micro array analysis reveals a novel hypoxia signal transduction pathway in human hepatocellular carcinoma cells. Int J Oncol 19:129- 135, 2001 Gong P, Hu B, Stewart D, Ellerbe M, Figueroa YG, Blank V, Beckman BS, Alam J. Cobalt induces heme oxygenase-1 expression by a hypoxia inducible factor-independent mechanism in Chinese hamster ovary cells. J Biol Chem 276:27018-27025, 2001 Weldon B, Burow ME, Rolfe KW, Clayton JL, Jaffe BM, Beckman BS. NF-B-mediated chemoresistance in breast cancer cells. Surgery 130:143-150, 2001 Burow ME, Weldon CB, Tang Y, McLachlan JA, Beckman BS. Oestrogen-mediated suppression of tumour necrosis factor alpha-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by antioestrogens. J Steroid Biochem Mol Biol 78:409-418, 2001. Weldon CB, Scandurro AB, Rolfe KW, Clayton JL, Elliott SE, Butler NN, Melnik LI, Alam J, McLachlan JA, Jaffe BM, Beckman BS, Burow ME. Identification of mitogen-activated protein kinase kinase 5 (MEK5) as a chemoresistance pathway in MCF-7 cells using gene expression microarray. Surgery 132:293-301, 2002 Figueroa, YG, Chan AK, Ibrahim R, Tang Y, Burow ME, Alam J, Scandurro AB, Beckman BS. NF-B plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expression. Expt Hematol 30: 1419-1427, 2002