CBR Signal Transduction Lab Publications   CBR Signal Transduction Lab Papers from 2000 to present   Struckhoff AP, Bittman R, Burow ME, Clejan S, Elliott S, Hammond T, Tang Y, Beckman BS. Novel ceramide analogs as potential chemotherapeutic agents in breast cancer. J Pharmacol Exp Ther 309:523-532, 2004. Weldon CB, Parker AP, Patten D, Elliott S, Tang Y, Frigo DE, Dugan CM, Coakley EL, Butler NN, Clayton JL, Alam J, Curiel TJ, Beckman BS, Jaffe BM, Burow ME. Sensitization of apoptotically-resistant Breast carcinoma cells to TNF and TRAIL by inhibityion of p38 mitogen-activated protein kinase signaling. Int J Oncol 24: 1473-1480, 2004. Frigo DE, Vigh KA Struckhoff AP, Elliott S, Beckman BS, Burow ME, McLachlan JA. Xenobiotic-induced TNF-a expression and apoptosis through the p38 MAPK signaling pathway. Carcinogenesis 25:249-261, 2003 Godin DA, Fitzpatrick PC, Scandurro B, Belafsky PC, Woodard BA, Amedee RG, Beech DJ, Beckman BS. PH-20: A novel tumor marker for laryngeal cancer. Arch Otolarnygol - Head Neck Surg 126:402- 404, 2000 Burow ME, Collins-Burow BM, Weldon CB, Lippel A, McLachlan JA, Clejan S, Beckman BS. Cross-talk between phosphatidylinositol 3-kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions. J Biol Chem 275:9628-9635, 2000 Burow ME, Weldon CB, Chiang T-C, Tang Y, Collins-Burow BM, Rolfe K, Li S, McLachlan JA, Beckman BS. Differences in protein kinase C and estrogen receptor a, b expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants. Int J Oncol 16:1179-1187, 2000 Burow ME, Weldon CB, Melnik LI, Duong BN, Collins-Burow BM, Beckman BS, McLachlan JA. PI3/K/AKT regulation of NF-kB signaling events in suppression of TNF-induced apoptosis. Biochem BiophysRes Commun 271:342-345, 2000 Scandurro AB, Weldon CB, Gutierrez YG, Alam J, Beckman BS. Gene micro array analysis reveals a novel hypoxia signal transduction pathway in human hepatocellular carcinoma cells. Int J Oncol 19:129- 135, 2001 Gong P, Hu B, Stewart D, Ellerbe M, Figueroa YG, Blank V, Beckman BS, Alam J. Cobalt induces heme oxygenase-1 expression by a hypoxia inducible factor-independent mechanism in Chinese hamster ovary cells. J Biol Chem 276:27018-27025, 2001 Weldon B, Burow ME, Rolfe KW, Clayton JL, Jaffe BM, Beckman BS. NF-B-mediated chemoresistance in breast cancer cells. Surgery 130:143-150, 2001 Burow ME, Weldon CB, Tang Y, McLachlan JA, Beckman BS. Oestrogen-mediated suppression of tumour necrosis factor alpha-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by antioestrogens. J Steroid Biochem Mol Biol 78:409-418, 2001. Weldon CB, Scandurro AB, Rolfe KW, Clayton JL, Elliott SE, Butler NN, Melnik LI, Alam J, McLachlan JA, Jaffe BM, Beckman BS, Burow ME. Identification of mitogen-activated protein kinase kinase 5 (MEK5) as a chemoresistance pathway in MCF-7 cells using gene expression microarray. Surgery 132:293-301, 2002 Figueroa, YG, Chan AK, Ibrahim R, Tang Y, Burow ME, Alam J, Scandurro AB, Beckman BS. NF-B plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expression. Expt Hematol 30: 1419-1427, 2002