At The Cutting Edge

1. Effects of estrogens on growth and reproduction of reef-building corals, Ann M. Tarrant, M.J. Atkinson, S. Atkinson

2. Vitamin A insufficiency accelarates the effect of endocrine disruptors, Keiko Nakahashi, Manabu Matsuda, Takao Mori

3. Phytochemical signaling and symbiotic gene activation are interrupted by endocrine disrupting chemicals, Jennifer E. Fox, Marta Starcevic, Kelvin Y. Kow, Matthew E. Burow, John A. McLachlan

4. Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine, Tomonari Matsuda, Jun Adachi, Yoshitomo Mori, Saburo Matsui, Hidetaka Takigami, Junko Fujino, Hiroko Kitagawa, Charles A. Miller III, Takaaki Kato and Kenichi Saeki

5. Sticky windows: Chemical and biological characteristics of organic film on Toronto windows, Erin Hodge, Miriam Diamond, Brian McCarry, Gary Stern, Patricia Harper

6. Dramatic enhancement of steroid hormone responses by eleven xenoestrogens combined at sub-threshold levels, Nissanka Rajapakse, Elisabete Silva and Andreas Kortenkamp

New Mechanisms - New Signals

7. Re-analysis of the mechanism of imposex induction: Integrating peptide hormones and steroid hormones, Eva Oberdörster and Patricia McClellan-Green

8. Xenobiotic regulation of the progesterone receptor in breast cancer cells, Lawanda Schief, Kathryn B. Horwitz and Thomas E. Wiese

9. Chaperones as regulators of aryl hydrocarbon (dioxin) receptor signaling, Charles Miller and Marc Cox

10. Crosstalk between phosphatidylinosital 3-Kinase/AKT and the estrogen receptor: A permissive role in cell survival, Bich N. Duong, Matthew E. Burow, Daniel E. Frigo, Steven Elliott, Christopher B. Weldon, Bridgette M. Collins-Burow, Jawed Alam, Barbara S. Beckman and John A. McLachlan

11. AKT and PTEN pathways are involved in the estrogen-dependent growth of primordial germ cells in vitro, Gerd H.G. Behrens, Francesca G. Klinger, Thomas Åbyholm & Massimo De Felici

12. The effects of DDT and its metabolites on AP-1 activity: mechanisms of environmental signaling, Daniel E. Frigo, Matthew E. Burow, Kamron A. Mitchell, Tung-Chin Chiang, and John A. McLachlan

13. Prevention of neonatal estrogen imprinting by vitamin A in the mouse vagina, Fujiko Masui, Manabu Matsuda, Yasuhisa Akazome, Takao Mori

14. Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function, Qing Zhou, Lane Clarke, Rong Nie, Kay Carnes, Li-Wen Lai, Yeong-Hau H. Lien, Alan Verkman, Dennis Lubahn, Jane S. Fisher, Benita S. Katzenellenbogen and Rex A. Hess

15. Xenohormones and prenatal androgen surge in male rats, T.Haavisto, J.Toppari, A. Adamsson, and J.Paranko

16. Treatment with aromatase inhibitor reverses the developmentally induced urethral dyssynergia in adult males, Tomi Streng, Mari Lehtoranta, Antti Talo, Risto Lammintausta and Risto Santti

17 Molecular analysis of murine external genitalia formation: Control of morphogenesis of genital tubercle by Shh and FGF system, G Yamada, K Suzuki, C.C. Hui, Y.Sato, M. Kamikawa, Y. Ogino , H Ogi and R Haraguchi

18. Effects of transgenerational exposure to estrogenic endocrine disrupters on maternal behavior and offspring development in mice, K.L. Howdeshell, P. Palanza, S. Parmigiani, F.S. vom Saal

19. Induction of CYP 1A1 and 1B1 in preimplantation rabbit blastocysts after exposure with defined PCB mixtures, Ina Meinicke and Bernd Fischer

20. Effects of Aroclor 1254 on the maturation and developmental competence of bovine oocytes in vitro, P. Pocar, T.A.L. Brevini, B. Fischer & F. Gandolfi

21. Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz, Anne Marie Vinggaard, Christine Nellemann, Majken Dalgaard and Helle Raun Andersen

22. Bisphenol A distribution and metabolism in pregnant CD1 mice, Daniel Zalko, Ana M. Soto, Laurence Dolo, Céline Dorio, Estelle Rathahao, Laurent Debrauwer and Jean-Pierre Cravedi

23. The interaction of air pollutants with the aryl hydrocarbon receptor and the estrogen receptor, Gail Klein, Patricia Harper, Tom Harner, Brian McCarry, Tom Dann, Terry Bidleman and Miriam Diamond

24. Estradiol dynamics: free in solution and bound to the estrogen receptor, Thomas C. Bishop, Kirk Williams, and Andrew Hall

Phytoestrogens

25. Cell-transforming and genotoxic activities of five phytoestrogens in cultured mammalian cells, Takeki Tsutsui, Yukiko Tamura, Eiichi Yagi and J. Carl Barrett

26. Genistein effects in mouse uterus and vagina, T. Sato, S. Yellayi, A. Naaz, M.A. Szewczykowski, J.S. Chang, W.G. Helferich and P.S. Cooke

27. Soy and reproductive development, Catherine Sandner, Rachel Ruhlen, Kembra Howdeshell, Julia Taylor, Fred vom Saal

28. Coumestrol inhibits the conversion of 5alpha -dihydrotestosterone to 5alpha -androstane-3alpha, 17beta-diol by 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) of human lung microsomes, Charles H. Blomquist, Paul H. Lima, Terrence P. Horrigan, and John R. Hotchkiss

29. The effect of phytoestrogens on the rat uterus, Y. Arao, A. Kikuchi, and F. Kayama

30. The effects of soy on obesity and related health issues, Rachel L. Ruhlen, Catherine M. Sandner, Kembra L. Howdeshell, Julia A. Taylor, Jeff Brose, S. Beckwith, F.H. Bronson, F.S. vom Saal

31. Phytoestrogens enhance working memory in a 90-minute delayed matching-to-place watermaze task, M. M. Martin, C.C. Gulledge, G. Dohanich, J.A. McLachlan

32. Dual effects of phytoestrogens result in U-shaped dose-response curves, Kristian Almstrup, Mariana F. Fernández, Jørgen H. Petersen, Nicolas Olea, Niels E. Skakkebæk and Henrik Leffers

Detection - Characterization

33. Evaluation of endocrine disruptors by DNA microarray, Hajime Watanabe, Atsuko Suzuki, Takeshi Mizutani, Hiroshi Handa, Taisen Iguchi

34. Endogenous estrogen-regulated genes as potential biomarkers for estrogenicity, Marianne Jørgensen, Niels-Erik Skakkebæk and Henrik Leffers

35. Data from an estrogen receptor-based biosensor demonstrates a differential response of hER to beneficial and harmful estrogenic compounds, Judith L. Erb, Eric A.E. Garber, James G. Downward IV, Eric M. Priuska, and James L. Wittliff

36. Foci formation of MCF7 human breast cancer cells as an in vitro screen for estrogenic chemicals, Enmin Zou

37. In vivo and in vitro bioassays for androgenicity in pulp and paper wastewater, van den Heuvel, M.R., Ellis, R.J., Bandelj, E., Stuthridge, T.R.

38. Evaluation of antiandrogenic activity of flutamide, vinclozolin, and procymidone in rodent 10-day Hershberger assay using immature rats, Soon Young Han, Hyung Sik Kim, Jae-Ho Shin, Hyun Ju Moon, Il Hyun Kang, Tae Sung Kim, In Young Kim, Ji-Hyun Seok, Hae Yeun Kil and Kwang Sik Choi

39. The use of stereology-based methods in order to estimate the number of Sertoli cells and diameter and length of the seminiferous tubules, Majken Dalgaard, Kirsten Pilegaard and Ole Ladefoged

40. Root extracts of panax ginseng and panax quinquefolias bind to estrogen alpha and beta receptors, SL Gray, BR Lackey, ND Camper

41. Effects of xenobiotic compounds on the expression of an estrogen regulated gene in tropical lizard anolis pulchellus, Jose A. Carde-Serrano, Lorena Saavedra, and M.H. Morales

42. Identification of differentially expressed genes during testosterone-induced sex-reversal in rana rugosa tadpoles, Minoru Takase, Taisen Iguchi, John Nielsen, Niels E. Skakkebaek and Henrik Leffers

43. Something from “nothing” – eight weak estrogenic chemicals combined at low ineffective levels produce significant mixture effects, Elisabete Silva, Nissanka Rajapakse and Andreas Kortenkamp

Wildlife

44. The biocide tributyltin alters testosterone esterification in mud snails (Ilyanassa obsoleta), Meredith P. Gooding and Gerald A. LeBlanc

45. Environmental antiecdysteroids alter embryo development in the crustacean daphnia magna, Xueyan Mu and Gerald A. LeBlanc

46. Effects of salt marsh methoprene exposure on female growth and reproduction in the Gulf sand fiddler crab, Uca panacea (Novak and Salmon, 1974) (Crustacea: Decapoda: Brachyura), Shea R. Tuberty, Sergio F. Nates, He Zhong, and Charles L. McKenney, Jr

47. The effect of 17-a-estradiol, diethylstilbestrol (DES), and genistein on xenopus laevis and rana pipiens tadpole development, Eric A.E. Garber , Amy M. McGarvey , Gerald L. Larsen , Judith L. Erb , and Heather Kirkpatrick

48. Spatial variation in phallus size, sex steroids, and vitellogenin in juvenile alligators collected from Lake Okeechobee and the Everglades, Mark P. Gunderson, Tom S. Breza, Matthew Milnes, Stefan A. E. Kools, and Louis J. Guillette Jr.

49. Effect of cadmium chloride on early stages of the germ cell lineage in Trachemys scripta embryos, Noppadon Kitana and Ian P. Callard

50. Effects of temperature on vitellogenin production in male western mosquitofish Gambusia affinis), Weaver, S.A., R.A. Angus, and R.D. Watson

51. Effects of exposure to a bioactive constituent of pulp mill effluent on the reproductive physiology of female mosquitofish gambusia affinis, Stanko, J.P., Dean, J., and Angus, R.A

52. Impaired sperm counts and testosterone dependent behavior in mosquitofish (Gambusia holbrooki) collected in or exposed to Lake Apopka water, Gunnar Toft, Thea Edwards, Erik Baatrup and Louis J Guillette Jr.

53. Endocrine disrupting effects of cattle feedlot effluenon the fathead minnow, pimephales promela, EF Orlando, G Binczik, J Gates, LE Gray, M Horton, A Kolak, C Lambright, and LJ Guillette, Jr.

54. Endocrine effects of paper mill effluent in longear sunfish, Jennifer A. Fentress, Henry L. Bart, Jr., Ann O. Cheek

55. Abnormal excess fat deposition in bluegill sunfish: an indication of impingement upon successful life history completion from exposure to treated waste effluents?, William P. Davis, Charles L. McKenney, Geraldine M. Cripe, Wallace T. Gilliam, Shea Tuberty and Sergio Nates

56. Altered metallothionein concentrations in liver and kidney of lake trout exposed to waterborne ethynylestradiol, J. Werner, R.E. Evans, K. Wautier, C. Baron and V. Palace

57. Disruption of the signalling pathway leading to cortisol synthesis in adrenal cells of rainbow trout (Oncorhynchus mykiss): effects of acute in vitro exposures to o,p¢-DDD and atrazine, Martin Lacroix & Alice Hontela

Populations

58. Health related research in the yukon river watershed: a bibliography and overview of research & research needs, Anna Godduhn and Lawrence Duffy

59. Potential health-impact of the Belgian PCB and Dioxin Incident in 1999, Jim Lafère, Jan Bernheim, Luc Hens, Paul Schepens, Nik Van Larebeke

60. Ethical challenges for xenoestrogen research: obstacles for epidemiological studies linking breast cancer and the environment, Lori Gruen and Claire Lutgendorf

61. Endocrine disruption in atlantic croaker: predicting population level response from laboratory studies, Murphy, C.A., Rose, K.A., Diamond, S.L ., Fuiman, L., McCarthy, I. , Alvarez, M. , Thomas P., Khan, I. , Ford, L.

62. A whole-lake estrogen addition experiment to assess relationships between organism- and population-level effects, K. Kidd, V. Palace, R. Evans, K. Mills, P. Blanchfield, M. McMaster, S. Brown, G. Van Der Kraak, D. Lattier and J. Lazorchak

Thursday, October 18, 2001

SESSION I: ENVIRONMENTAL FACTORS AND HUMAN SEXUAL DEVELOPMENT
~ Dedicated to Al Bongiovanni ~

Chair: MELVIN GRUMBACH, Department of Pediatrics, University of California, San Francisco.

PAOLO MOCARELLI, University of Milano-Bicocca and Department of Laboratory Medicine Hospital of Desio, Milan, Italy, Dioxin Exposures in Seveso and Ratios of Offspring.

CARLOS BOURDONY, Pediatric Endocrinology & Diabetes Division, San Juan City Hospital, and Department of Pediatrics, University of Puerto Rico School of Medicine, Premature Sexual Development in Puerto Rico: Past, Present & Future.

VALERIE WILSON, Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, Louisiana, Introduction of Greater New Orleans Foundation (GNOF) Distinguished Lecturer on Women’s Health and the Environment.

MARCIA HERMAN-GIDDENS, GNOF Distinguished Lecturer on Women’s Health and the Environment, NC Child Advocacy Institute and School of Public Health, University of North Carolina, Chapel Hill, Too Much, Too Early: Puberty, Culture, and Environment.

 

SESSION II: SEX REVERSAL: FISH

Chair: IAN CALLARD, Department of Biology, Boston University.

PETER MATTHIESSEN, Centre for Ecology and Hydrology, UK, Partial Sex Reversal in UK Fish -- Does It Matter?

JAMES NAGLER, Department of Biological Sciences, University of Idaho, Moscow, Intersex and Sex Reversal in Fishes.

PETER THOMAS, Department of Marine Science, University of Texas, Austin, Er gamma in Fish.

JENNIFER FOX, Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, Louisiana, Phytochemical Signaling and Symbiotic Gene Activation are Interrupted by Endocrine Disrupting Chemicals.

POSTER SESSION AND PRE-DINNER RECEPTION

Chair: TOM WIESE, Center for Bioenvironmental Research at Tulane & Xavier Universities,
New Orleans, Louisiana

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Friday, October 19, 2001

SESSION III: HORMONALLY ACTIVE AGENTS IN THE ENVIRONMENT
Chair: ANN CHEEK, Department of Biological Sciences, Southeastern Louisiana University.

SHINSUKE TANABE, Center for Marine Environmental Studies, Ehime University, Matsuyama, Japan, Global Distribution of Environmental Hormones.

DOUGLAS MEFFERT, Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, Louisiana, and ANGELA L. H. PREIMESBERGER, Environmental Toxicology Consultant, Minneapolis, Minnesota, Human and Ecological Species Integration for Functionally-Based Assessments: A Bisphenol-A Case Study.

TYRONE HAYES, Department of Integrative Biology, University of California, Berkeley, Ecologically Relevant Doses of Atrazine Disrupts Sex Differentiation in the African Clawed Frog Xenopus Laevis.

CAROL METEYER, USGS-National Wildlife Health Center, Madison, Wisconsin, Encyclopedia of Frog Malformations in the Wild.

MARY BETH MARTIN, Lombardi Cancer Center, Georgetown University, Washington, DC, Cadmium: An Endocrine Disrupter?

VANCE TRUDEAU, Department of Biology and Centre for Advanced Research in Environmental Genomics, University of Ottawa, Canada, Expression Profiling Estrogen and Xenoestrogen Action in the Non-mammalian Vertebrate Brain.

 

SESSION IV: MECHANISMS OF ENVIRONMENTAL HORMONE ACTION

Chair: GEORGE STANCEL, Graduate School of Biomedical Sciences, University of Texas, Houston.

HORST MICHNA, German Sport University, Cologne, Environmental Estrogens Antagonize Sex Hormone Action in a Tissue Specific Manner.

DOUGLAS STOCCO, Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, The Role of the Star Protein in Steroid Hormone Biosynthesis.

VINCENT LAUDET, Ecole Normale Supérieure de Lyon, France, Orphan Nuclear Receptors and Evolution.

JOE THORNTON, Earth Institute and Department of Biological Sciences, Columbia University, New York, Evolution of Steroid Hormones and Receptors: Exploiting Duplicated Genes and Biosynthetic Intermediates.

JINQIANG CHEN, Johns Hopkins School of Public Health, Baltimore, Maryland, ERa and ERb: Mitochondrial Localization and Role in Mitochondrial DNA Transcription.

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Saturday, October 20, 2001

SESSION V: HORMONES IN MALE REPRODUCTIVE TRACT DEVELOPMENT

Chair: TAISEN IGUCHI, Center for Bioenvironmental Research, National Basic Biology Institute, Japan.

REX HESS, Reproductive Biology and Toxicology, University of Illinois, Estrogens and Fertility in the Male.

JANE FISHER, Medical Research Council, Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, Scotland, Estrogen-Androgen Interactions in Development of the Male Reproductive System.

GAIL PRINS, University Andrology Laboratory, College of Medicine, University of Illinois, Chicago, Estrogen in Prostate Development.

AXEL THOMSON, Medical Research Council, Human Reproductive Sciences Unit, Centre for Reproductive Biology Edinburgh, Scotland, Role of Androgens and Fibroblast Growth Factors in Prostatic Development.

PASCAL BERNARD, Human Genetics, School of Medicine, University of California, Los Angeles, Dosage-Sensitive Sex Reversal In Mammals.

GEN YAMADA, Center for Animal Resources and Development, Kumamoto University, Japan, External Genitalia: Development and Evolution.

 

SESSION VI: ENVIRONMENTAL ESTROGEN FACTORS AND BREAST DISEASE

Chair: SUZANNE SNEDEKER, Program on Breast Cancer and Environmental Risk Factors in New York State, Cornell University, New York.

RUTHANN RUDEL , Silent Spring Institute, Newton, Massachusetts, Characterization of Residential Exposures to a Wide Range of Endocrine-Active Compounds in the Context of a Breast Cancer Epidemiologic Study.

KIRSTEN MOYSICH , Roswell Park Cancer Institute, Buffalo, New York, Organochlorines and Breast Cancer: Old News or New Challenges.

FEDERAL PROGRAMS IN ENDOCRINE DISRUPTION: PRIORITY NEEDS AND FUTURE DIRECTIONS

Chair: ELAINE FRANCIS, United States Environmental Protection Agency, Washington, DC

MICHAEL GALVIN, National Institute for Occupational Safety and Health, Centers for Disease Control, Atlanta, Georgia

SARAH GEROULD, Contaminants Program, United States Geological Survey, Reston, Virginia

DOUGLAS MEFFERT, Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, Louisiana

Closing Remarks: JOHN MCLACHLAN, Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, Louisiana

Disclosure Statement

It is the policy of the Center for Continuing Education at Tulane University Health Sciences Center to ensure balance, independence, objectivity and scientific rigor in all its educational programs. All faculty participating in these programs are expected to disclose to the program audiences any real or apparent conflict of interest related to the content of their presentations. This information pertains to relationships with pharmaceutical companies, biomedical device manufacturers or other corporations whose products or services are related to the subject matter of the presentation topic or products in the research and development phase.