Signals and Mechanisms

1. Endocrine Disruptors Potentiate Coactivators: The role of MAPKs, Daniel E. Frigo, Matthew E. Burow, Jawed Alam, and John A. McLachlan

2. AKT and MAPK regulation of ERb-mediated transcription through AF-2 recruitment/activation of p160 Coactivators, Bich N. Duong, Steven Elliott, Lilia I. Melnik, Barbara S. Beckman, Jawed Alam, John A. McLachlan and Matthew E. Burow

3. Expression of Cofactors in Mouse Uterus and Vagina after Stimulation of Diethylstilbestrol or Bisphenol-A, Tomomi Sato and Taisen Iguchi

4. Effect of Neonatal Treatment with Bisphenol-A on the Rat Uterus with Reference to Decidual Response, Ohta, Y., Saishu, N., Ishibashi, T., Iguchi, T

5. The Xenoestrogen Bisphenol-A Stimulates Inappropriate Prostate Cancer Cell Growth and Tumor-Derived Androgen Receptor Activity, Yelena Wetherill, Ann Staubach, Christin Petre, Kelly Monk, Alvaro Puga, Xu-Bao Shi, and Karen E. Knudsen

6. Infantile Exposure to 4-Tert-Octylphenol Interferes with the Rat Ovarian Steroidogenesis, Sari Myllymaki, Marika Karjalainen, Jorma Toppari, Jorma Paranko

7. Diethylstibestrol (DES) induces Abnormal Uterine Differentiation, Wei-Wei Huang, Qun Bi, Jussi Vuoristo, Tung-Chin Chiang, John Mclachlan and Liang MA

8. The Molecular Mechanism of Diethylstilbestrol (DES) -Induced Genital Tract Lesions, Takeshi Kurita, Alea A. Mills and Gerald R. Cunha

9. Stilbene Chemicals: Potential Disrupters of Diverse Signaling Systems, Erica N. Simpson, Jennifer E. Fox, and John A. McLachlan

10. Production And Metabolism Of Bioactive Hydroxy-Estrogens By Target Cancer Cells In Vivo And In Vitro, L. Castagnetta, R. Stefano, V.

11. Vitamin A Modifies the Effects of Perinatal Treatment with Estrogen on the Mouse Genital Tracts, Manabu Matsuda, Fujiko Masui, Keiko Nakahashi, and Takao Mori

12. Long-Term Exposure to b-Hexachlorocyclohexane Promotes Transformation and Invasiveness of MCF7 Human Beast Cancer Cells, Enmin Zou and Fumio Matsumura

13. An Investigation of the Endocrine Disrupting Potential of Organophosphate Pesticides, Shala L. Thomas, Suzanne Nehls and Thomas E. Wiese

14. Xenoestrogenic Compounds from Plastic Containers Bind to Estrogen Receptors a and b (ERa and ERb) and Affect Breast Cancer Cell Proliferation, Sandra Gray, Patilee Tate, Brett Lackey and Susan Gray

15. Interaction Kinetics of Estrogen Receptors with Estrogen Response Elements, Matthewos Eshete and William L. Alworth

16. Evaluation of the Estrogenic Effects of Legume Extracts Containing Phytoestrogens, Stephen M. Boué, Thomas E. Wiese, Suzanne Nehls, Matthew Burow, Steven Elliot, Carol H. Carter-Wientjes, Betty Y. Shih, and Thomas E. Cleveland


Wildlife Exposure and Mechanisms

17. The ING Tumor Suppressor Protein is Regulated by Thyroid Hormone in the Xenopus laevis Tadpole and is Affected by the Herbicide Acetochlor, M.J. Wagner, K. Cheung, K. Werry, and C.C. Helbing

18. Identification of Phosphoproteome Components Important in Thyroid Hormone-Induced Metamorphosis of the Xenopus laevis Tadpole, D. Domanski, and C. C. Helbing

19. Investigation of the Effects of Atrazine on the Gonadal Differentiation in the Hermaphroditic Mangrove Killifish, Rivulus marmoratus, WP Davis, KJ Bogel, G Cripe, B Doheney, A Thiyagarajah, EF Orlando

20. Abnormal Vitellogenin Production in vivo and Alterations of Aromatase Activity in vitro due to Organochlorine Contaminants in Sea Turtles, Jennifer M. Keller, Patricia McClellan-Green

21. Testosterone:Fatty Acid Esterification: A Novel Target of Endocrine Disruption Caused by Tributyltin, Meredith P. Gooding and Gerald A. LeBlanc

22. Effects of a nonylphenol- and phytoestrogen-enriched diet on the production of plasma vitellogenin, steroid hormone, hepatic cytochrome P450 IA and glutathione-S-transferase activities in goldfish, Carassius auratus, K. Arizono, H. Ishibashi, R. Shinkura, M. Yamamoto

23. Identification of Differentially Expressed Genes during Estrogen-Induced Sex- Reversal in Rana Rugosa Tadpoles, Minoru Takase, Taisen Iguchi, John Nielsen, Niels E. Skakkebaek & Henrik Leffers

24. The Androgen Dependent Expression of Secondary Sexual Character in Fish: Gonopodium Formation of Mosquitofish Gambusia affinis, Yukiko Ogino, Hironori Katoh, and Gen Yamada

25. Thyroid Hormones and the Effects of Contaminants in Steller sea lions (Eumetopias jubatus), Matthew J. Myers and Shannon Atkinson

26. Effects of Paper and Pulp Mill Exposure on the Reproductive Physiology of Lepomis macrochirus in Elevenmile Creek, Jeanine R. Burse, Ann O. Cheek, Henry L. Bart, Jr.

27. Gonadotropin and Estrogen Responses in Wild Caught Turtles (Chrysemys picta) from Cape Cod, Massachusetts, Noppadon Kitana, Seung Jae Won and Ian P. Callard


Human Effects

28. Inverted Offspring Sex Ratio in Specific Occupations, El Safty A.M.K., Attia D.I.

29. Total Dioxins and Furans Modify the Association of PCBs with Thyroid Hormones in Adults Consuming Great Lakes Fish, Mary Turyk, Victoria Persky, Henry A. Anderson, Lawrence P Hanrahan, Claire Falk, Dyan N. Steenport , Robert Chatterton, Jr., Jr., Sally Freels, and the Great Lakes Consortium

30. Gynaecological Disturbances Among Females Engaged in the Manufacture of Sex Hormones, El-Samra G.H., Siha M.S., El-Safty A.M.K. Abd-El-Badii M.

31. Is Gulf War Syndrome an Endocrine Disorder?, Cynthia V. Rider and Gerald A. LeBlanc


In Search of New Signals

32. Development of ELISA for Quantitative Analysis for Environmental Hormones, Shigeru Fujimoto, Yasuhiro Goda, Ayako Kobayashi, Masato Hirobe, Michihiko Ike, Masanori Fujita

33. Yeast Oestrogen Assays: a Comparison of Different Reporter Genes and human Oestrogen Receptors a and b, Toine F.H. Bovee, Richard J.R. Helsdingen and Ron L.A.P. Hoogenboom

34. Endocrine Disruptor Studies and Reverse Toxicology, Jun Kanno, Katsuhide Igarashi, Kenichi Aisaki, Atsushi Ono, and Tohru Inoue

35. Choriogenins as Biomarkers for Estrogen-induction in Louisiana wildlife, Gary J. LaFleur, Jr, Christie Landry, Cass Stevens

36. The Effects of Flutamide and Diethylstilbestrol Exposure on the Reproductive Organs and Thyroid of Male Rats by the Rodent 20-day Thyroid/Pubertal Assay, Jae-Ho Shin, Hyung Sik Kim, Hyun Ju Moon, Il Hyun Kang, Tae Sung Kim, Ji Hyun Seok, In Young Kim, and Soon Young Han

37. Modeling Simulations of the Ligand-Receptor Interactions of Environmental Chemicals Bound to the Estrogen Receptor, T. E. Wiese and S. Nehls

38. EPA’s Endocrine Disruptor Screening Program, Greg Schweer and Elaine Francis

Thursday, October 17th

SESSION I: HORMONES AND THE ENVIRONMENT: A GLOBAL PERSPECTIVE

Chair: Akira Arimura Tulane University, Department of Neuroendocrinology, Health Sciences Center, New Orleans, Louisiana

"Discovery of the First Hormone: A Shared Experience Between Japan and New Orleans."

Noboru Takasugi (Yokohama University, Japan), President Emeritus, Yokohama University, Japan
"Impact of Developmental Endocrine Research in Japan."

Howard Bern (University of California, Berkeley), Professor Emeritus, University of California, Berkeley
"What We Know About Endocrine Disruption and How We Know It."

Terri Damstra (World Health Organization), International Program on Chemical Safety, World Health Organization, Research Triangle Park, North Carolina
"World Health Organization Global Assessment of the State-of-the-Science of Endocrine Disrupting Chemicals"

SESSION II: CELL SIGNALING AND HORMONE ACTION: THE EMERGING PARADIGM

Chair: Barbara Beckman (Tulane University) Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, Louisiana

Jan-Ake Gustafsson Karolinska Institutet, Sweden, Center for Nutrition & Toxicology, Karolinska Institute, Stockholm, Sweden
"Environmental Signals: Multiple Receptors and Multiple Inputs."

Margaret Warner (Karolinska Institutet, Sweden), Center for Nutrition & Toxicology, Karolinska Institute, Stockholm, Sweden
“The Roles of ER-alpha and ER-beta in Cell and Tissue Function.”

David Armstrong (NIEHS), Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
"Racking Your Brain for Thyroid Hormone: Following an Old Hormone Down a New Pathway."

Trevor Archer (NIEHS), Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
"Estrogen-induced Chromatin Remodeling.”

Valerie Wilson (Tulane University CBR), Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, Louisiana

Introduction of Benita Katzenellenbogen

Benita Katzenellenbogen (University of Illinois at Urbana-Champaign), GNOF Distinguished Lecturer on Women's Health and the Environment, Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign
"Estrogen Signaling: The Importance of Molecular Biology in Women’s Health.”

POSTER SESSION and PRE-DINNER RECEPTION

Chair: Tom Wiese (Tulane University), Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, Louisiana

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Friday, October 18th

SESSION III: ECOLOGICAL SIGNALS A

Chair: Ann Cheek (Southeastern Louisiana University), Department of Biological Sciences, Southeastern Louisiana University, Hammond

Tyrone Hayes (University of California, Berkeley), Department of Integrative Biology, University of California, Berkeley
"The Common Pollutant, Atrazine, Alters the Sexual Development of Male Frogs.”

Caren Helbing (University of Victoria), Department of Biochemistry & Microbiology, University of Victoria, British Columbia
“Thyroid Hormone Signaling: A Lesson From Frogs.”

Susan Jobling (Brunel University), Department of Biological Sciences, Brunel University, Uxbridge, UK
"Why Won't Boy Fish Be Boy Fish?"
 

ECOLOGICAL SIGNALS B

Chair: Eva Oberdoerster, Department of Biology, Southern Methodist University, Dallas, Texas

Jorge Cortés, CIMAR Ciudad de la Investigación, Universidad de Costa Rica, San Jose
“In Corals, No Sex is No Problem.”

Ann Tarrant, Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts
"Spawning to Sewage: Estrogens on Coral Reefs."

Jose Vargas, CIMAR Ciudad de la Investigación, Universidad de Costa Rica, San Jose
“Ecological Considerations in Invertebrate Health: Results from a Costa Rican Coastal Pollution Survey.”

SESSION IV: CHEMICAL APPROACHES TO ENDOCRINE DISRUPTING CHEMICALS

Chair: Philip Jones, Xavier University, New Orleans, Louisiana

Matthew Burow (Tulane University), Department of Medicine, Tulane University Health Sciences Center
"Cellular Biology of Estrogenic Signaling: A Case for Convergence."

Paul Erhardt (University of Toledo), Center for Drug Design and Development, University of Toledo, Ohio
“Chemical Fingerprinting of Natural Matrices Having Anticancer Properties. ”

Dana Kolpin, (United States Geological Society), Iowa City
“Inventory of Pharmaceutical Chemicals and Other Biologically Active Pollutants in U.S. Streams and Rivers.”

NEW INVESTIGATION REPORTS
Chair: Joe Thornton, Center for Ecology & Evolutionary Biology, University of Oregon, Eugene

BANQUET
Location: Audubon Tea Room, Audubon Zoo
Entertainment: The Soul Rebels Brass Band

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Saturday, October 19th

SESSION V: IN VITRO & IN VIVO MODEL SYSTEMS FOR STUDYING ENDOCRINE DISRUPTION

Chair: Taisen Iguchi, Center for Bio-environmental Research, National Basic Biology Institute, Japan

Koji Arizono (Prefectural University of Kumamoto, Japan), Kumamoto University, Kumamoto, Japan
“Standardization of Animal Models for Endocrine Disruption Research.”

Carol Swartz (National Institute of Environmental Health Sciences), NIEHS, Research Triangle Park, North Carolina
"Immortalized Human Uterine Cell Lines as Model Systems to Study Hormones and Other Environmental Chemicals."

Yasuhiro Tomooka (National Institute of Agrobiological Resources, Japan), Department of Biological Science and Technology, Tokyo University of Science, Noda, Japan
“Immortalized Mouse Cell Lines from Reproductive Tract and Brain."

Thomas Wiese (Tulane University), Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, Louisiana
"Molecular Determinants of the Estrogen, Androgen, and Progestin Activities of Environmental Hormones."

SESSION VI: RESPONSE TO ECOSYSTEM PERTURBATION

HUMAN

Chair: William Toscano (University of Minnesota), Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis

Jun Sekizawa (NIHS, Japan), National Institute of Health Sciences, Tokyo, Japan
“Is Sex Ratio Decline of Offspring in Japan Related to Dioxin Body Burden?"

ECOSYSTEM WIDE

Chair: Louis Guillette (University of Florida), Department of Zoology, University of Florida, Gainesville

Robert Twilley (University of Louisiana at Lafayette), Center for Ecology and Environmental Technology, University of Louisiana at Lafayette
“From Environmental Hormones to Ecological Habitats: Defining Models of Ecosystem Self-Organization.”

Michael DePledge (University of Plymouth), Environment Agency, Bristol, UK
“The Marine Environment as a Determinant of Ecosystem and Human Health.”

Disclosure Statement

It is the policy of the Center for Continuing Education at Tulane University Health Sciences Center to ensure balance, independence, objectivity and scientific rigor in all its educational programs. All faculty participating in these programs are expected to disclose to the program audiences any real or apparent conflict of interest related to the content of their presentations. This information pertains to relationships with pharmaceutical companies, biomedical device manufacturers or other corporations whose products or services are related to the subject matter of the presentation topic or products in the research and development phase.