e.hormone environmental signaling epigenetics lead in the environmental

e.hormone 2008 Conference

The Cutting Edge of Endocrine Disrupter Research
6th Annual Symposium on the Environment and Hormones
October 27-30, 2004
Hosted by: Tulane/Xavier Center for Bioenvironmental Research

  • General Information
  • Poster Abstracts
  • Conference Program
General Information

We contend that the phenomenon known as endocrine disruption is a manifestation of a larger biological issue – that is, the complex signaling networks that exist within and between organisms. These signaling networks can be maintained or perturbed by environmental factors. At e.hormone we intend to develop the tools for a new science of environmental signaling and to invite participants to further develop the Environmental Signaling Network (an NSF-sponsored activity).

Poster Abstracts

1.  High-Throughput Detection of Polycyclic Aromatic Hydrocarbons Using a Yeast-Based Aryl Hydrocarbon Receptor Signaling Assay; Abeer Alnafisi, Janet Hughes, Guangdi Wangand Chuck Miller

2.  A Rapid method to Quantify Estrogenic Compounds in Wastewater with Recombinant Yeast; Joseph C. Colosi, Maura E. Scolere and Arthur D. Kney

3.  Intersex and other forms of reproductive disruption in feral white sucker (Catostomus commersoni) downstream of wastewater treatment plant effluent in Boulder, Colorado; Alan M. Vajda, Elena M. Lopez, John D. Woodling, and David O. Norris

4.  Vitellogenin Detection in Caiman latirostris (Crocodylia: Alligatoridae). A Tool to Assess Xenoestrogen Exposure; Rey F, Ramos JG, Stoker C, Beldoménico PM, Bussmann LE, Luque EH, Muñoz-de-Toro M

5.  Ovarian Features in Xenoestrogen-determined Females of Caiman latirostris; Stoker C, Beldoménico PM, Rodríguez HA, Rey F, Muñoz-de-Toro M, Luque EH

6.  Utilizing the Spotted Rose Snapper (Lutjanus guttatus) as an Indicator of endocrine Disrupting Chemicals in the Pacific Coast of Costa Rica; Lee, J; Johanning, KM; Cheek, A, Vargas, JA, Bonilla, J; and McLachlan, JA

7.  Mysid Crustaceans as Test Organisms for the Evaluation of Environmental Endocrine Disruption; Tim Verslycke, An Ghekiere, Nancy Fockedey, Charles McKenney, Jr. and Colin Janssen

8.  Chitinase Activity in the Epidermis of the Fiddler Crab, Uca pugilator, as an in vivo Screen for Molt-Interfering Xenobiotics; Enmin Zou and Ryan Bonvillain

9.  External Features of Several Sexually Abnormal Fiddler Crabs, Uca pugilator; Enmin Zou

10.  Anecdotal evidence of  Reproductive Abnormalities in Louisiana Estuarine Species; Jennifer V. Lasseigne, Justin Getzinger, Jessica Occhinero, Lois Nelson, Gary LaFleur, Jr

11.  Decreased Apoptosis in the Forebrain of Adult Male Medaka (Oryzias latipes) After Aqueous Exposure to Ethinylestradiol; Elizabeth A. Stokes, William Lonergan, Lynn P. Weber, David M. Janz, Ann A. Poznanski, Gordon C. Balch, Chris D. Metcalfeand Matthew S. Grober

12.  Cd Exposures during Development in Fathead Minnows: Effects on Reproductive Physiology and Reproductive Success; Marlo K. Sellin and Alan S. Kolok

13.  Glucocorticoid-Induced Disruption of Vertebral Development in the Fathead Minnow, Pimephales promelas; Warner, Kara E and Jenkins, Jeffrey J.

14.  The Dysregulation of Testosterone Esterification by Tributyltin in a Prosobranch Gastropod (Ilyanassa obsoleta); Robin M. Sternberg, Meredith P. Gooding, and Gerald A. LeBlanc

15.  Hypoxia Suppresses Reproduction in Gulf Killifish, Fundulus grandis; Christie A. Landry1, Steve Manning2, and Ann O. Cheek

16.  Assessment of Molecular Interaction between Low Oxygen and Estrogen in Fish Cell Culture; Johanning, KM; Lee, J; Wiese, T; Beckman, B; McLachlan, JA; and Rees, BB

17.  Xenoestrogen Action in Breast Cancer: Impact on ER-dependent Transcription and Mitogenesis;  Hess-Wilson JK, Boldison J, Weaver K, and Knudsen KE

18.  Microarray Anaylsis of Human Immortalized Uterine Lieomyoma Cells; M. M. Martin, T.C. Chiang, Neysa Garner, and J.A. McLachlan

19.  Characterization of Rapid Estrogen Actions in Uterine Smooth Muscle and Leiomyoma Cells; Erica Nierth-Simpson, Lilia Melnik, and John A. McLachlan

20.  Nongenomic Androgen Signaling in the Ovary; Stacy White and Stephen Hammes

21.  Diversity and Expression of Estrogen Receptor-Related Receptors (ERRs) in the Killifish Fundulus heteroclitus; Ann M. Tarrant and Mark E. Hahn

22.  Functional Analysis of Paralogous Estrogen Receptor Family Genes of Sea Snail, Thais clavigera; Masaaki Kajiwara, Itsuka Akiyama, Kenichi Kato, Shigeru Takahashi, and Yuji Takahashi

23.  Effect of the anti-androgenic endocrine disruptor vinclozolin on song rate, activity, and body composition of a temperate songbird (Junco hyemalis); Danielle Satre, Larry A. Adamson, Cynthia Corbitt

24.  Uranyl Nitrate Mimics Estrogen Activity In vivo and In vitro; Whish SR*, Mayer LP, Robinson ZD, Layton TM, Hoover A, Winterton B, Begay A, Benally D, Poyer D, Hoyer PB, Dyer CA

25.  Effects of in utero Exposure to Di(n-butyl)phthalate or Flutamide on Gene Expression of Male Rats Reproductive Organs; Tae Sung Kim, Tae Seok Kang, Hyun Ju Moon, Il Hyun Kang, In Young Kim, Young Sun Song, and Soon Young Han

26.  Reproductive Failure in Female Rats Given Bisphenol-A Neonatally; Ohta, Y.1, Ishibashi, T.1, Kato, H.2, Iguchi, T.

27.  Chronic Restraint Stress Alters Neuronal Morphology in Limbic Brain Regions, As Well As Emotionality: The Effect of Estrogen; G. E. Wood1, R. Mitra2, B.S.S. Rao3, S. Chatterji2, B. S. McEwen

28.  Feline Embryo Culture:  Detection of Estrogen Receptor Alpha and Progesterone Recptor in In Vitro Produced Embryos, Uterus and Ovary; M.W. Latino, T. C. Chiang, C. E. Pope, M. Gomez, B. L. Dresser, J.A. McLachlan

29.  Studies Toward the Synthesis of Potential Estrogen Mimics; Ashton T. Hamme, Jun Wang, Erick Ellis, Tiffany Cook, and Tom Wiese

30.  Total Synthesis of the Soybean Flavonoids Glyceollin I and II; Rahul Khupse and Paul Erhardt

31.  Computational Modeling of the Interactions Between Flavonoids and the Human Estrogen Receptor; Peter I. Nagy, Wieslaw A. Klis and Paul W. Erhardt

32.  Quantification and Stability of Soybean Phytoestrogens by HPLC; Mugunthu R. Dhananjeyan and Paul W. Erhardt

33.  Effect of Glycosylation on Soy Flavonoid Anticancer and Antioxidant Activity; Nicole Ellis, Jeffery Sarver and Paul Erhardt

34.  Antioxidant Activity of Soybean Phytoalexins; Stephen M. Boué, Betty Y. Shih, Carol H. Carter-Wientjes, John A. McLachlan, and Thomas E. Cleveland

35.  Response of Soy Cultures to Biological Elicitors of Fungal and Algal Origin; S. P. Kale, S. Boue, S. Khan, K. Rajasekaran, B. Shih, M. Boissiere, J. McLachlan, and T.E. Cleveland

36.  The in vitro Estrogen and Androgen Activity of the Lydia Pinkham Herbal Supplement; Michelle Lang, Thomas E. Wiese, Ashley White, Huiming Li, Stephen M. Boué

37.  The Influence of Alternative Herbal Menopause Treatments on the Proliferation of MCF-7 Breast Cancer Cells; Ashley L. White, Thomas E. Wiese, Suzanne Nehls, Steve Boue

38.  Are High Doses of Isoflavones Neurotoxic to the Aging Brain?; Monica Unseld, Shakira Blanton, and Cynthia Corbitt

39.  Dietary Phytoestrogens and Photoperiodic Response in Male Dark-Eyed Juncos (Junco hyemalis); Cynthia Corbitt , Larry A. Adamson, Danielle Satre, and George E. Bentley

40.  Endocrine Disruptors: Epidemiologic Approaches; Barbara S. Glenn, PhD, MPH1, Michael Galvin, PhD, Kumiko Iwamoto, PhD, Kimberly Gray, PhD, Elaine Francis, PhD

41.  Preconception DDT and Pregnancy Loss: A Prospective Study Using a Biomarker of Pregnancy; Scott A.Venners, Changzhong Chen, Xiping Xu, Lingling Wang, Xiaobin Wang

42.  Fetal Exposure Assessment of Multiple Persistent Chemicals by Measuring PCBs Concentration in Human Umbilical Cords or Maternal Serum; Hideki Fukata and Chisato Mori

Conference Program
Wednesday, October 27, 2004
9:00 am – 4:00 pm Environmental Signaling 101:
the Basics of Endocrine Disruption
  (all-day workshop; sponsored by the National Science Foundation)
6:00 – 8:00 pm e.hormone welcome reception
Thursday, October 28, 2004
7:45 – 8:45 am continental breakfast and registration continued
  opening remarks and introduction…
9:00 – 9:30 am JOHN McLACHLAN, PhD
Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, LA
Session 1 Environmental Signals and Sensors
9:30 – 10:10 am JAN-AKE GUSTAFSSON, MD, PhD
Department of Medcial Nutrition and Department of Biosciences
Karolinska Institutet, Sweden
"New surprises in estrogen signaling"
10:10 – 10:50 am THEODORE SLOTKIN, PhD
Professor, Pharmacology, Psychiatry and Neurobiology
Duke University Medial Center

"Sex and the (Neurotoxi)City"
10:50 – 11:20 am break (with group photo)
Cold Spring Harbor Labs, NY
"pagen@uic: A Program for Global Promoter Analysis for Gene Expression and Regulation"
11:50 – 12:30 pm TOSHIHIRO HORIGUCHI, PhD
National Institute for Environmental Studies, Japan
“The Retinoid X Receptor has an Important Role in the Development of Imposex Caused by Organotin Compounds in Gastropods”
12:30 – 2:00 pm lunch
Session 2 Endocrine Disruption: Gene-Environment Interaction
2:00 – 2:40 pm JIMMY L. SPEAROW, PhD
Department of Environmental Toxicology
University of California at Davis

"Strain Differences in Susceptibility to Endocrine Disruption: Implications for the Design of Toxicological Screening Assays, or Are We Testing on Bambi or King Kong?"
2:40 – 3:20 pm JULIUS THIGPEN, PhD
National Institute of Environmental Health Sciences,
Research Triangle Park, North Carolina

"Why Phytoestrogen-Reduced Rodent Diet(s) Should be Used When Evaluating the Potential Estrogenic Activity of Endocrine Disruptor Compounds"
3:20 – 3:50 pm break
3:50 – 4:30 pm KENNETH NEPHEW, PhD
Departments of Cellular & Integrative Physiology and Obstetrics & Gynecology, Indiana University School of Medicine
“Regulation of Estrogen Receptor Target Genes”
4:30 – 5:10 pm BENSON AKINGBEMI, PhD
Center for Biomedical Research, Population Council
New York City
, NY
“Phthalate-induced Leydig Cell Hyperplasia is Associated with Multiple Endocrine Disturbances”
5:10 – 5:40 pm high school student presentations
Poster Session with Mingling, Munching, and Music
6:00 – 8:30 pm Chair: THOMAS WIESE
Xavier University, New Orleans, LA
Friday, October 29, 2004
7:45 – 8:45 am continental breakfast
Workshop – Estrogens and Development: Translation of Field, Laboratory, and Clinical Findings into Human Health Outcomes
9:00 – 9:20 am JOHN McLACHLAN, PhD
Center for Bioenvironmental Research at Tulane & Xavier Universities, New Orleans, LA
“What Do We Mean By Developmental Estrogenization Syndrome?”
9:20 – 9:50 am JEFF BOYD, PhD
Gynecology and Breast Research Laboratory
Memorial Sloan-Kettering Cancer Center, NYC

“Is There a Molecular Basis for Developmental Estrogenization Syndrome?”
9:50 – 10:20 am Group Discussion

Karolinska Institutet, Sweden
10:20 – 10:50 am break
10:50 – 11:10 am TAISEN IGUCHI, PhD
Center for Bioenvironmental Research, Japan
“Estrogens and Development in Laboratory Animals”
11:10 – 11:30 am ANN CHEEK, PhD
Southeastern Louisiana University, Hammond
“Environmental Estrogens and Developmental Effects in Wildlife”
11:30 – 12:00 pm Group Discussion
Chair: Louis Guillette, PhD

University of Florida at Gainesville
12:00 – 1:00 pm lunch
Ochsner Clinic Foundation, New Orleans, LA
“Prenatal Effects of Synthetic Estrogens in Humans”
Tulane University Medical Center, New Orleans, LA
“Pregnancy Complications, Hormone Levels, and Human Health”
1:40 – 2:00 pm break
2:00 – 2:20 pm Scott Kerlin
DES Sons International Network, Kingston, Ontario, Canada
2:20 – 3:00 pm NIELS SKAKKEBAEK, MD, D.M.Sc
University of Copenhagen, Denmark
“Testicular Dysgnesis Syndrome and Environment”
3:00 – 3:30 pm Group Discussion

University of Missouri, Columbia
3:30 – 4:00 pm Wrap Up

Center for Bioenvironmental Research, New Orleans, LA
Author, Austin, Texas
4:00 – 5:00 pm “Connections in the Environment: Real Life Experience with Estrogen” - Film Viewing: Healthy Baby Girl
Connections in the Environment: Perspectives from the Arts
7:00 – 10:00 pm Banquet; Wax Museum, French Quarter
Saturday, October 30, 2004
These sessions are being presented by the Environmental Protection Agency as part of the e.hormone conference. This day of conference activities is included in the e.hormone registration fee. There is also a day rate available for those who wish to attend the Saturday sessions only.
7:45 – 8:45 am continental breakfast
Session 3 Endocrine Disrupters: Epidemiologic Approaches
9:00 – 9:15 am Chairs:
U.S. Environmental Protection Agency
National Cancer Institute, National Institutes of Health
9:15 – 9:40 am SHANNA H. SWAN, PhD
University of Missouri, Columbia, MO
“Phthalates in Pregnant Women and Children”
9:40 – 10:05 am XIAOBIN WANG, ScD
Children’s Memorial Hospital Medical School, Chicago, IL
“DDT, Endocrine Disruption and Reproductive Outcomes”
10:05 – 10:30 am LAURA FENSTER, PhD
California Department of Health Services, Oakland, CA
“Endocrine Disrupters and Neurodevelopmental Outcomes”
10:30 – 10:55 am JAMES H. RAYMER, PhD
Research Triangle Institute, Research Triangle Park, NC
“Epidemiologic Evaluation of Perfluorooctyl Compounds”
10:55 – 11:20 am TONGZHANG ZHENG, MD
Yale University, New Haven, CT
“PCBs, CYP1A1 Polymorphism and Breast Cancer Risk”
11:20 – 11:45 am VICTORIA HOLT, PhD
Fred Hutchinson Cancer Research Center, Seattle, WA
“Persistent Organic Pollutants and Endometriosis Risk”
11:45 – 12:00 pm group discussion
12:00 – 1:00 pm lunch
Session 4 Endocrine Disrupters: Epidemiologic Approaches - Part II
1:10 – 1:30 pm RUSS HAUSER, MD, MPH, ScD
Harvard School of Public Health
"Dioxins, Male Pubertal Development and Testis Function"
1:30 – 1:50 pm DEAN B. BAKER, MD, MPH
University of California at Irvine
"Latent Effects of Gestational Exposure to Heptachlor"
1:50 – 2:10 pm IRVA HERTZ-PICCIOTTO, PhD
University of California at Davis
"Early Childhood Development and PCB Exposures in Slovakia"
1:50 – 2:10 pm PHILIPPE A. GRANDJEAN, MD
Harvard School of Public Health, Boston, MA
"Effects of Perinatal Endocrine Disrupters in Children"
2:10 – 2:30 pm PAMELA IMM, MS
Wisconsin Department of Health and Family Services
"Endocrine Disrupting Chemical and Thyroid Outcomes"
2:30 – 2:50 pm STEVEN SCHWARTZ, MD
Fred Hutchinson Cancer Research Center, Seattle, WA
"Persistent Organochlorines and Testicular Cancer Risk"
2:50 – 3:10 pm break
3:10 – 4:40 pm Panel Discussion: Translation of Research into Public Health Practice and Policy
HAROLD ZENICK, National Health and Environmental Effects Research Laboratory
U.S. Environmental Protection Agency
R. DELON HULL, PhD, National Institute for Occupational Safety and Health, Centers for Disease Control
LUANN WHITE, PhD, Center for Applied Environmental Public Health, Tulane University
MARK DICKIE, PhD, University of Central Florida, Orlando
  This panel discussion will explore the interface between basic and applied health research as applied to risk prevention/reduction and the promotion of health. The panel represents varied perspectives in this area including policymakers, regulators, researchers, medical practitioners, the regulated community, and environmental public health advocates.
4:45 – 5:00 pm evaluations and adjournment
Disclosure Statement
It is the policy of the Center for Continuing Education at Tulane University Health Sciences Center to ensure balance, independence, objectivity and scientific rigor in all its educational programs. All faculty participating in these programs are expected to disclose to the program audiences any real or apparent conflict of interest related to the content of their presentations. This information pertains to relationships with pharmaceutical companies, biomedical device manufacturers or other corporations whose products or services are related to the subject matter of the presentation topic or products in the research and development phase.