A gateway to environmental signaling

e.hormone 2010

30th Anniversary Celebration of 1st Estrogens in the Environment Meeting, October 20-24, 2009

  • Poster Abstracts
  • Conference Program

Click here to download poster abstracts in PDF

1. Eutrophication is Environmental Obesity And Other Stories of Excess

Thea M. Edwards

Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

2. Environmental Activism at Music Festivals

Anna Whalen

Tulane University, Department of Environmental Studies, New Orleans, Louisiana

3. The Evolution of Estrogenicity: How Has the Ligand Evolved?

Robert Wallace, Bo Han, Michelle Lacey, and John McLachlan

Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

4. Umbilical Cord Serum Organochlorines and Child Language Development: a Cohort Study

Scott A. Venners1, Glenys M. Webster2, Sally W. Thurston3, Changzhong Chen4, Susan Korrick4,5

1Simon Fraser University, Faculty of Health Sciences, Burnaby, British Columbia, Canada; 

2University of British Columbia, School of Environmental Health, Vancouver, British Columbia, Canada;

3University of Rochester, Department of Biostatistics and Computational Biology, Rochester, New York, USA; 

4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; 

5Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA

5. Perimenstrual Chocolate Cravings and the Physical and Affective Correlates of Menstruation

Julia M. Hormes, M.A.1, 2, Paul Rozin1, Ph.D. & Ellen W. Freeman, Ph.D.3

1Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104

2Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500, N. State Street, Jackson, MS 39216

3Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, 3701 Market Street, 8th Floor, Philadelphia, PA 19104

6. Sentinels and Sensors:  The DES-Exposed Human Offspring

Kari Christianson, Pat Cody, Karen Fernandes, Frances Howell, Stephanie Kanarek, and Cheryl Roth

DES Action USA, P.O. Box 7296, Jupiter, FL  33468

7. Exposure Assessment of Breastfed Infants to Peristent Organic Pollutants in Hungary

Éva Vigh1, Andrea Colombo2, Emilio Benfenati2, Helen Håkansson3, Marika Berglund3, József Bódis4, János Garai1

1Department of Pathophysiology and Gerontology; 4Department of Obstetrics and Gynecology; University of Pécs, Medical School, Pécs, Hungary

2Mario Negri Institute for Pharmacological Research, Department of Environmental Health Sciences, Milan, Italy

3Karolinska Institute, Institute of Environmental Medicine, Stockholm, Sweden

8. Phytoestrogens and Other Plant Phenols Affect Macrophage Migration Inhibitory Factor Enzymatic Activity and Tubulin Polymerization

Éva Vigh, Piroska .Gabrieli, Edit Schumacher, Valéria Molnar, János Garai

Department of Pathophysiology and Gerontology, University of Pécs, Medical School, Pécs HUNGARY

9. Application of a Zebrafish Estrogen Receptor Binding Assay for Ecological Risk Assessment of Endocrine Active Substances

A. Tarrant1, C. Mori2, S. Thakali2, M. Sharma2, H. Yekel3and T. Verslycke2

1Woods Hole Oceanographic Institution, Woods Hole, MA, USA

2Gradient Corporation, Cambridge, MA, USA

3Wyeth Pharmaceuticals, Malvern, PA, USA

10. Localization of Steroid Receptors in the Chicken Yolk-sac Membrane

Pat Kasinpila, Lori C. Albergotti, and Louis J. Guillette, Jr.

Department of Biology, University of Florida, Gainesville, FL

11. Estrogen Receptor a is Indispensable for the Induction of Persistent Vaginal Change by Neonatal 5a-Dihydrotestosterone Exposure

Shinichi Miyagawa1, Yoshinao Katsu1, Yasuhiko Ohta2, Tamotsu Sudo3, Dennis B. Lubahn4 and Taisen Iguchi1,*

12. Rapid Regulation of KATP Channel Activity by 17-beta - Estradiol in Pancreatic beta-Cells Involves the Estrogen Receptor beta and the Atrial Natriuretic Peptide Receptor

Sergi Soriano1,  Ana B. Ropero1, Paloma Alonso-Magdalena1, Cristina Ripoll1, Ivan Quesada1, Esther Fuentes1, Brigit Gassner2, Michaela Kuhn2, Jan-Ake Gustafsson3,4 and Angel Nadal1

1Instituto Bioingeniería and CIBERDEM, Universidad Miguel Hernández, Elche 03202, Alicante, Spain.

2Institute of Physiology, University of Würzburg;Germany.

3Departament of Biosciences and Nutrition, Karolinska Institute, Novum, Huddinge, Sweden.

4Departament of Cell Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, USA

13. Cadmium and Other Metals Ions Lack Endocrine Disrupting Activity in Yeast and Mammalian Reporter Assays

Xiaobing Tan1, Thomas Wiese2 and Charles Miller1

1Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine

2Xavier University of Louisiana, College of Pharmacy2, New Orleans, LA

14. Toxic and Genotoxic Studies of Wood Dusts

Wilson, Mark1, Rando, Roy1,4, Miller, Charles1,2,3, Tan, Xiaobing1

1Environmental Health Sciences, Tulane University, New Orleans, LA, USA.

2Tulane Cancer Center, Tulane University, New Orleans, LA, USA.

3Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

4Environmental Medicine, Tulane University, New Orleans, LA, USA.

15. Alkylphenols Affect Multiple Responses in Lobster Molting and Metamorphosis

Hans Laufer1,5, Ming Chen1, Brian Baclaski1, James Stuart2, James Bobbitt2, Molly W. Jacobs1,4, Michael Johnson1, Yuegang.Zuo3, Zhuo Zhu.3

1University of Connecticut, Department of Molecular and Cell Biology

2U.Conn, Dept. of Chemistry

3U.Mass, Dartmouth

4Woods Hole Oceanographic Inst.

5Marine Biological Laboratory, Woods Hole, MA.

16. Differences Between Rat and Human Metabolism of Bisphenol A: Using In Vitro Kinetic Parameters To Extrapolate To In Vivo Intestinal Metabolism Rates

Janet K. Hess-Wilson1, Christopher S. Mazur2, John F. Kenneke2, John C. Lipscomb1

1 U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Cincinnati, Ohio

2 U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Athens, Georgia

17. Tissue Reconstruction: Uterine Fibroids and the Possible Role of Bisphenol A

Chasity B. Coleman1 and John A. McLachlan1,2,3

1Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

2Tulane Cancer Center, Tulane University, New Orleans, Louisiana

3Department of Pharmacology, Tulane Medical School, New Orleans, Louisiana

18. Isolation Of Tumor Initiating Cells With Metastatic Potential From Human Primary Invasive Ductal Carcinoma

Carolyn Marsden1,2, Mary Jo Wright2,5, Latonya M. Carrier1,5, Radhika Pochampally3,5,6 and Brian G. Rowan1,5

1Department of Structural and Cellular Biology,

2Department of Surgery,

3Department of Pharmacology,

4Environmental Health Sciences,

5Tulane Cancer Center, and

6Center for Gene Therapy, Tulane University Health Science Center, New Orleans LA 70112

19. CXCR4 Expression Mediates Hormone Independence and Endocrine Therapy Resistance through Erk1/2 and p38 Signaling

Lyndsay V. Rhodes1, Nicole F. Neel3, Yun Zhu1, Virgilio A. Salvo1, Juan P. Fonseca1, Steven Elliott1, Henry C. Segar1, Becky Worthylake4, Bridgette Collins-Burow1, Mien-Chie Hung5, Ann Richmond2, 3, Matthew E. Burow1

1Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana

2Departments of Veterans Affairs and

3Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee

4Department of Pharmacology, Louisiana State University Health Science Center, New Orleans, Louisiana

5Department of Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX

20. Organochlorine-mediated Phosphorylation of the General Coactivator CBP through p38 Mitogen Activated Protein Kinase

Melyssa R. Bratton2,5, Daniel E. Frigo1,2, Katinka A. Vigh2, Daju Fan6, Scott Wadsworth7, John A. McLachlan2, and Matthew E. Burow2,3,5

1Molecular and Cellular Biology Program

2Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

3Department of Medicine-Section of Hematology and Medical Oncology

4Department of Surgery, and the

5Department of Pharmacology, Tulane University Health Science Center, New Orleans, LA

6Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710

7Johnson & Johnson Pharmaceutical Research & Development, Raritan, NJ 08869-0602

21. Overexpression of miR-155 Disrupts ER Signaling in MCF-7 Breast Cancer Cells

Elizabeth Martin1, Syreeta Tilghman4, Steven Elliott1, Mona Jodari-Karimi1, Lyndsay Rhodes1, Erik Flemington3, and Matthew E. Burow1,2,5

Departments of 1Medicine, 2Pharmacology, 3Pathology and Laboratory Medicine

4Pulmonary Diseases Critical Care and Environmental Medicine

5Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

22. Endocrine Disruptor Regulation of miR-21 Expression in Breast Cancer Cells

Syreeta L. Tilghman1, Melyssa R. Bratton2, Henry C. Segar, Elizabeth Martin, Hideo Iba3, John A. McLachlan2,4, Thomas Wiese5, Kenneth Nephew6 and Matthew E. Burow1,4

School of Medicine, Section of Hematology & Medical Oncology1 Pharmacology2, Tulane University, New Orleans, LA 70112

3Institute of Medical Science, University of Tokyo, Tokyo, Japan

4Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

5College of Pharmacy, Xavier University, New Orleans, LA 70125

6School of Medicine, Indiana University, Bloomington, Indiana 47405

23. Sphingosine Kinase: A Novel Therapeutic Target for ER Signaling in Breast Cancer

James W. Antoon1, Martin D. White1, William D. Meacham1, Evelyn M. Slaughter1, Shannon E. Muir1, Steven Elliott2, Lyndsay V. Rhodes2, Hasina B. Ashe3, Thomas E. Wiese3, Charles D. Smith4, Matthew E. Burow2, Barbara S. Beckman1

Tulane Departments of Pharmacology1, Medicine, Section of Hematology & Medical Oncology2, Tulane University School of Medicine, New Orleans, LA 70112

3College of Pharmacy, Xavier University, New Orleans, LA 70112;

4Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425.

24. KX-01, a Novel Src kinase Inhibitor directed towards the Peptide Substrate site, Induces Robust Apoptosis and Synergizes with Tamoxifen and Chemotherapy in Breast Cancer

Muralidharan Anbalagan1, Latonya Carrier1, David Hangauer2, 3 and Brian G. Rowan1

1Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA

2Kinex Pharmaceuticals LLC

3State University of New York at Buffalo, Buffalo, New York

25. In Vitro Subcutaneous Absorption of Fenthion using Female Abdominal Skin

Annette M. Hormann

Southern Illinois University-Carbondale, Illinois 62901 USA

26. Interactions of Estrogenic Pesticides on Breast Cancer Cell Gene Expression Evaluated with a Cancer Focused PCR Array System

H. Chris Segar1,2, Elena V. Skripnikova2, Huiming Li2, Thomas E. Wiese2

1Biomedical Sciences Program, Tulane University School of Medicine

2Xavier University of Louisiana College of Pharmacy, New Orleans, LA

27. Sample Preparation of Wastewater and Dissolved Solids for Use in an Estrogen Responsive Cellular Bioassay

Adam B, Streiffer1, Thomas Wiese2, Ponsawat Srisawat3, Deborah Grimm4

1*ERM, 3838 N. Causeway Blvd., STE 2725, Metairie, LA 70002

2Xavier University of Louisiana College of Pharmacy, New Orleans, LA, 70125

3Dept. of Environmental Health, School of Public Health, Tulane University, New Orleans, LA, 70112

4Coordinated Instrumentation Facility, Tulane University, New Orleans, LA, 70118

28. A Compilation of Suspected Environmental ED Sites in Louisiana

Rhea Vidrine, Gary LaFleur, Jr.

Biological Sciences, Nicholls State University, Thiobdaux, LA 70310

29. Reproductive Disruption of Fishes by Endocrine-Active Wastewater Effluent

Alan Vajda1, L.B. Barber2, A.B. Bolden3, and D.O. Norris3

1Department of Integrative Biology, University of Colorado, Denver

2U.S. Geological Survey, Boulder, Colorado

3Department of Integrative Physiology, University of Colorado, Boulder

30. Mechanisms for Inhibition of Crustacean Molting by Organochlorines: an In vitro Approach

Yanling Meng and Enmin Zou

Department of Biological Sciences, Nicholls State University, Thibodaux, LA 70310, USA

31. Alterations of a Biomarker for Molting in the Brown Shrimp, Penaeus aztecus, Subjected to Hypoxia and Sedimentary Naphthalene

Enmin Zou

Department of Biological Sciences, Nicholls State University, Thibodaux, LA 70310, USA

32. Investigation of the Causes of Gonadal Abnormalities in the Chalcalburnus tarichi

Guler Unal1, Emily Marquez1, Mara Feld1, Ahmet R. Oguz2, Burak Kaptaner2 and Ian P. Callard1

1Boston University, Department of Biology, 5 Cummington St., Boston, MA 02215

2Yuzuncu Yil University, Department of Biology, Van 65080-Turkey

33. A Preliminary Study on Immunohisitochemical Detection of Estrogen Receptor in American Alligator Oviducts – Specificity of Antibodies

Ohta, Y.1, Urushidani, H. 2, Takeuchi, T. 1, Iguchi, T. 2, Katsu, Y. 3, Kohno, S. 4, Brandon, M. 4 and Guillette, L.J. 4

1Department of Veterinary Science, Faculty of Agriculture, Tottori, Japan

2Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, Okazaki, Japan

3Laboratory of Reproductive and Developmental Biology, Graduate School of Life Science, Hokkaido University

4Department of Zoology, Florida University, Gainesville, FL, USA

34. Morphological and Molecular Responses in Oviducts of 4 Month-old, FSH-Stimulated Alligators

Brandon C Moore1, Sara Forouhar2, Nicole L. Botteri2, Heather J. Hamlin2 and Louis. J. Guillette, Jr.2

1Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

2Department of Biology, University of Florida, Gainesville, FL

35. Effects of Embryonic Exposure to Dieldrin and p,p’-DDE on Endocrine Mediated Signaling in the Danio rerio and Trachemys scripta Models

Mara H. Feld1, Giuseppe Cullaro1, Emily Marquez1, Guler Unal3, Pericles Stavropoulos2, Ian P. Callard1

1Department of Biology, Boston University, Boston MA 02215

2Department of Chemistry, Missouri University of Science and Technology, Rolla MO 65409

3Department of Biology, Yuzunca Yil University, Van Turkey

36. Epithelial Morphology of the American Alligator Phallus

Ketan K. Mathavan, Brandon C. Moore, and Louis J. Guillette, Jr.

Department of Biology, University of Florida, Gainesville, FL

37. Environmental Influence on Yolk Steroids in American Alligators (Alligator mississippiensis)

Hamlin, H.J., Albergotti, L.A., Mutz, J, Guillette, L.J.Jr.

Department of Biology, 223 Bartram Hall, PO Box 118525, University of Florida, Gainesville, Florida, 32611-8525 USA

38. A Novel Approach to the Investigation of Environmental Endocrine Disruptors: Ecotoxicogenomics in the American Alligator (Alligator mississipiensis)

Scott M. Clayman1, Satomi Kohno1, Ashley S. P. Boggs1, Russell H. Lowers2 and Louis J. Guillette Jr.1

1University of Florida, Department of Biology, Gainesville, FL

2Dynamac Corporation, Kennedy Space Center, FL

39. The Medullary Rest: A Naturally Occurring Intersex Region of American Alligator Ovary

Nicole L. Botteri, Brandon C. Moore, Heather J. Hamlin, Ashley N. Lawler, Ketan Mathavan, and Louis J. Guillette, Jr.

Department of Biology, University of Florida, Gainesville, FL

40. Diagnostic Thyroid Histology of Neonatal American Alligators

Ashley S. P. Boggs1, Eugenia Timofeev1, Ketan Mathavan1, Louis J. Guillette Jr.1

1University of Florida, Department of Biology

41. Exploring Steroidogenesis in the Chorioallantoic Membrane of the Domestic Chicken (Gallus gallus) and the American Alligator (Alligator mississippiensis)

Lori C. Albergotti1, Heather J. Hamlin1, Michael W. McCoy1,2, and Louis J. Guillette, Jr.1

1Department of Biology, University of Florida, Gainesville, FL,

2Department of Integrative Biology, University of South Florida, Tampa, FL

Wednesday, October 21, 2009

Morning Session
Perspectives (30 years back and 30 years forward)
Chairperson:  Paul Galand

Research Talk I:
Estrogens in the Environment: From the Very Beginning
John A. McLachlan

Research Talk II:
Estrogens and Cell Proliferation: Perspectives
Carlos Sonnenschien

Research Talk III:
Estrogen receptor activities outside the nucleus
Ellis Levin

Research Talk IV:
Disruption of Endocrine System at the Control Level
Andrea Gore

Research Talk V:
Estrogen Receptor Beta and Hormonally Active Chemicals
Jan-Ake Gustafsson

Lunch/Graduate Student Round Table Discussion with Cindy Corbitt and Dana McDowelle

Afternoon Session
Endocrine Mechanisms – Imprinting and Epigenetics
Chairpersons:  David Crews and Melvenia Martin

Research Talk I:
The Role of Epigenetics in Development and Cancer
Shuk-mei Ho

Research Talk II:
Estrogen, Androgen, and Epigenetic Prostate Disease
Gail Prins

Research Talk III:
Epigenetics in Kidney Development in Humans
Samir El Dahr

Research Talk IV:
Transgenerational Effects of Endocrine Disrupting Chemicals
Mike Skinner

e. hormone Poster Session/Reception
Facilitators and Organizers: KiTani Parker-Johnson and Tom Wiese

Thursday, October 22, 2009

Morning Session
The DES Experience - A Model for Environmental Endocrine Disruption and Transgenerational Disease
Chairpersons: John A. McLachlan and Bich Duong

Research Talk I:
Developmental Exposure to DES
Retha Newbold

Research Talk II:
Gene Imprinting with DES in Rats
Cheryl Walker

Research Talk III:
Recent Results with DES Exposed Humans
Linda Titus-Ermstoff

Research Talk IV:
Epigenetics, Estrogen, and Development
Doug Ruden

Personal Experiences and Speculation in DES Exposure, Lindsey Berkson
Discussion of DES exposure-Lessons Learned, DES Action and audience

Afternoon Session
Endocrine Mechanisms – Signaling and Evolution
Chairpersons:  Chris Williams and Jennifer Fox

Research Talk I:
Evolution of Steroidal Hormonal Response
Michael Baker

Research Talk II:
Evolution of Nuclear Receptors
Joe Thornton

Research Talk III:
Hormonally Active Chemicals Across Various Species
Ann Tarrant

Research Talk IV:
Bisphenol-A: a New Risk Factor for Type II Diabetes
Angel Nadal

Research Talk V:
Androgen and Estrogen Signaling and Gene Regulation
Dan Frigo

Research Talk VI:
Environmental signaling
Charles Miller

Friday, October 23, 2009

Morning Session
Biologically-Active Agents in the Environment
Chairperson:  John Peterson Myers and Florastina Payton

Research Talk I:
Green Chemistry Approach to Endocrine Disruption
Terry Collins

Research Talk II:
Plant Estrogens and anti-estrogens: the yin and yang of signaling
Matt Burow

Research Talk III:
Bisphenol A and Breast or Reproductive Disease
Ana Soto

Research Talk IV:
Bisphenol A Mechanisms, Activity and Impact
Fred vomSaal

Research Talk V:
Hormonal Responses to Light at Night
David Blask

Afternoon Session
Ecosystem wide effects of environmental signaling
Chairpersons:  Mike Blum and Brandon Moore

Research Talk I:
Biologically Active Chemicals in the Water Stream
Deborah Swackhamer

Research Talk II:
Hydrologic approach to EDC and pharmaceuticals in water
Larry Barber

Research Talk III:
Endocrine Disruption and Development: Sex Determination and Behavior
David Crews

Anniversary Gala

Saturday, October 24, 2009

Morning Session
Urban and Ecosystem Signaling
Chairpersons:  Bill Toscano and Thea Edwards

Research Talk I:
Biologically active Contaminants in the waste stream
AJ Englande

Research Talk II:
Systems Wide Approach to Endocrine Disruptions
Lou Guillette

Research Talk III:
Endocrine disruption across multiple animal species – common mechanisms?
Taisen Iguchi

Research Talk IV:
Real Life Impacts of Endocrine Disruptions
Tyrone Hayes

Wrap Up/Adjournment

Disclosure Statement

It is the policy of the Center for Continuing Education at Tulane University Health Sciences Center to ensure balance, independence, objectivity and scientific rigor in all its educational programs. All faculty participating in these programs are expected to disclose to the program audiences any real or apparent conflict of interest related to the content of their presentations. This information pertains to relationships with pharmaceutical companies, biomedical device manufacturers or other corporations whose products or services are related to the subject matter of the presentation topic or products in the research and development phase.