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1. Eutrophication is Environmental Obesity And Other Stories of Excess

Thea M. Edwards

Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

2. Environmental Activism at Music Festivals

Anna Whalen

Tulane University, Department of Environmental Studies, New Orleans, Louisiana

3. The Evolution of Estrogenicity: How Has the Ligand Evolved?

Robert Wallace, Bo Han, Michelle Lacey, and John McLachlan

Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

4. Umbilical Cord Serum Organochlorines and Child Language Development: a Cohort Study

Scott A. Venners¹, Glenys M. Webster², Sally W. Thurston³, Changzhong Chen⁴, Susan Korrick^4,5

¹Simon Fraser University, Faculty of Health Sciences, Burnaby, British Columbia, Canada; 

²University of British Columbia, School of Environmental Health, Vancouver, British Columbia, Canada;

³University of Rochester, Department of Biostatistics and Computational Biology, Rochester, New York, USA; 

⁴Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; 

⁵Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA

5. Perimenstrual Chocolate Cravings and the Physical and Affective Correlates of Menstruation

Julia M. Hormes, M.A.^{1, 2}, Paul Rozin¹, Ph.D. & Ellen W. Freeman, Ph.D.³

¹Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104

²Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500, N. State Street, Jackson, MS 39216

³Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, 3701 Market Street, 8th Floor, Philadelphia, PA 19104

6. Sentinels and Sensors:  The DES-Exposed Human Offspring

Kari Christianson, Pat Cody, Karen Fernandes, Frances Howell, Stephanie Kanarek, and Cheryl Roth

DES Action USA, P.O. Box 7296, Jupiter, FL  33468

7. Exposure Assessment of Breastfed Infants to Peristent Organic Pollutants in Hungary

Éva Vigh¹, Andrea Colombo², Emilio Benfenati², Helen Håkansson³, Marika Berglund³, József Bódis⁴, János Garai¹

¹Department of Pathophysiology and Gerontology; ⁴Department of Obstetrics and Gynecology; University of Pécs, Medical School, Pécs, Hungary

²Mario Negri Institute for Pharmacological Research, Department of Environmental Health Sciences, Milan, Italy

³Karolinska Institute, Institute of Environmental Medicine, Stockholm, Sweden

8. Phytoestrogens and Other Plant Phenols Affect Macrophage Migration Inhibitory Factor Enzymatic Activity and Tubulin Polymerization

Éva Vigh, Piroska .Gabrieli, Edit Schumacher, Valéria Molnar, János Garai

Department of Pathophysiology and Gerontology, University of Pécs, Medical School, Pécs HUNGARY

9. Application of a Zebrafish Estrogen Receptor Binding Assay for Ecological Risk Assessment of Endocrine Active Substances

A. Tarrant¹, C. Mori², S. Thakali², M. Sharma², H. Yekel³and T. Verslycke²

¹Woods Hole Oceanographic Institution, Woods Hole, MA, USA

²Gradient Corporation, Cambridge, MA, USA

³Wyeth Pharmaceuticals, Malvern, PA, USA

10. Localization of Steroid Receptors in the Chicken Yolk-sac Membrane

Pat Kasinpila, Lori C. Albergotti, and Louis J. Guillette, Jr.

Department of Biology, University of Florida, Gainesville, FL

11. Estrogen Receptor a is Indispensable for the Induction of Persistent Vaginal Change by Neonatal 5a-Dihydrotestosterone Exposure

Shinichi Miyagawa¹, Yoshinao Katsu¹, Yasuhiko Ohta², Tamotsu Sudo³, Dennis B. Lubahn⁴ and Taisen Iguchi^1,*

12. Rapid Regulation of K_ATP Channel Activity by 17-beta - Estradiol in Pancreatic beta-Cells Involves the Estrogen Receptor beta and the Atrial Natriuretic Peptide Receptor

Sergi Soriano¹,  Ana B. Ropero¹, Paloma Alonso-Magdalena¹, Cristina Ripoll¹, Ivan Quesada¹, Esther Fuentes¹, Brigit Gassner², Michaela Kuhn², Jan-Ake Gustafsson^3,4 and Angel Nadal¹

¹Instituto Bioingeniería and CIBERDEM, Universidad Miguel Hernández, Elche 03202, Alicante, Spain.

²Institute of Physiology, University of Würzburg;Germany.

³Departament of Biosciences and Nutrition, Karolinska Institute, Novum, Huddinge, Sweden.

⁴Departament of Cell Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, USA

13. Cadmium and Other Metals Ions Lack Endocrine Disrupting Activity in Yeast and Mammalian Reporter Assays

Xiaobing Tan¹, Thomas Wiese² and Charles Miller¹

¹Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine

²Xavier University of Louisiana, College of Pharmacy², New Orleans, LA

14. Toxic and Genotoxic Studies of Wood Dusts

Wilson, Mark¹, Rando, Roy^1,4, Miller, Charles^1,2,3, Tan, Xiaobing¹

¹Environmental Health Sciences, Tulane University, New Orleans, LA, USA.

²Tulane Cancer Center, Tulane University, New Orleans, LA, USA.

³Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

⁴Environmental Medicine, Tulane University, New Orleans, LA, USA.

15. Alkylphenols Affect Multiple Responses in Lobster Molting and Metamorphosis

Hans Laufer^1,5, Ming Chen¹, Brian Baclaski¹, James Stuart², James Bobbitt², Molly W. Jacobs^1,4, Michael Johnson¹, Yuegang.Zuo³, Zhuo Zhu.³

¹University of Connecticut, Department of Molecular and Cell Biology

²U.Conn, Dept. of Chemistry

³U.Mass, Dartmouth

⁴Woods Hole Oceanographic Inst.

⁵Marine Biological Laboratory, Woods Hole, MA.

16. Differences Between Rat and Human Metabolism of Bisphenol A: Using In Vitro Kinetic Parameters To Extrapolate To In Vivo Intestinal Metabolism Rates

Janet K. Hess-Wilson¹, Christopher S. Mazur², John F. Kenneke², John C. Lipscomb¹

¹ U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Cincinnati, Ohio

² U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Athens, Georgia

17. Tissue Reconstruction: Uterine Fibroids and the Possible Role of Bisphenol A

Chasity B. Coleman¹ and John A. McLachlan^1,2,3

¹Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

²Tulane Cancer Center, Tulane University, New Orleans, Louisiana

³Department of Pharmacology, Tulane Medical School, New Orleans, Louisiana

18. Isolation Of Tumor Initiating Cells With Metastatic Potential From Human Primary Invasive Ductal Carcinoma

Carolyn Marsden^1,2, Mary Jo Wright^2,5, Latonya M. Carrier^1,5, Radhika Pochampally^3,5,6 and Brian G. Rowan^1,5

¹Department of Structural and Cellular Biology,

²Department of Surgery,

³Department of Pharmacology,

⁴Environmental Health Sciences,

⁵Tulane Cancer Center, and

⁶Center for Gene Therapy, Tulane University Health Science Center, New Orleans LA 70112

19. CXCR4 Expression Mediates Hormone Independence and Endocrine Therapy Resistance through Erk1/2 and p38 Signaling

Lyndsay V. Rhodes¹, Nicole F. Neel³, Yun Zhu¹, Virgilio A. Salvo¹, Juan P. Fonseca¹, Steven Elliott¹, Henry C. Segar¹, Becky Worthylake⁴, Bridgette Collins-Burow¹, Mien-Chie Hung⁵, Ann Richmond^{2, 3}, Matthew E. Burow¹

¹Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana

²Departments of Veterans Affairs and

³Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee

⁴Department of Pharmacology, Louisiana State University Health Science Center, New Orleans, Louisiana

⁵Department of Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX

20. Organochlorine-mediated Phosphorylation of the General Coactivator CBP through p38 Mitogen Activated Protein Kinase

Melyssa R. Bratton^2,5, Daniel E. Frigo^1,2, Katinka A. Vigh², Daju Fan⁶, Scott Wadsworth⁷, John A. McLachlan², and Matthew E. Burow^2,3,5

¹Molecular and Cellular Biology Program

²Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

³Department of Medicine-Section of Hematology and Medical Oncology

⁴Department of Surgery, and the

⁵Department of Pharmacology, Tulane University Health Science Center, New Orleans, LA

⁶Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710

⁷Johnson & Johnson Pharmaceutical Research & Development, Raritan, NJ 08869-0602

21. Overexpression of miR-155 Disrupts ER Signaling in MCF-7 Breast Cancer Cells

Elizabeth Martin¹, Syreeta Tilghman⁴, Steven Elliott¹, Mona Jodari-Karimi¹, Lyndsay Rhodes¹, Erik Flemington³, and Matthew E. Burow^1,2,5

Departments of ¹Medicine, ²Pharmacology, ³Pathology and Laboratory Medicine

⁴Pulmonary Diseases Critical Care and Environmental Medicine

⁵Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

22. Endocrine Disruptor Regulation of miR-21 Expression in Breast Cancer Cells

Syreeta L. Tilghman¹, Melyssa R. Bratton², Henry C. Segar, Elizabeth Martin, Hideo Iba³, John A. McLachlan^2,4, Thomas Wiese⁵, Kenneth Nephew⁶ and Matthew E. Burow^1,4

School of Medicine, Section of Hematology & Medical Oncology¹ Pharmacology², Tulane University, New Orleans, LA 70112

³Institute of Medical Science, University of Tokyo, Tokyo, Japan

⁴Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

⁵College of Pharmacy, Xavier University, New Orleans, LA 70125

⁶School of Medicine, Indiana University, Bloomington, Indiana 47405

23. Sphingosine Kinase: A Novel Therapeutic Target for ER Signaling in Breast Cancer

James W. Antoon¹, Martin D. White¹, William D. Meacham¹, Evelyn M. Slaughter¹, Shannon E. Muir¹, Steven Elliott², Lyndsay V. Rhodes², Hasina B. Ashe³, Thomas E. Wiese³, Charles D. Smith⁴, Matthew E. Burow², Barbara S. Beckman¹

Tulane Departments of Pharmacology¹, Medicine, Section of Hematology & Medical Oncology², Tulane University School of Medicine, New Orleans, LA 70112

³College of Pharmacy, Xavier University, New Orleans, LA 70112;

⁴Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425.

24. KX-01, a Novel Src kinase Inhibitor directed towards the Peptide Substrate site, Induces Robust Apoptosis and Synergizes with Tamoxifen and Chemotherapy in Breast Cancer

Muralidharan Anbalagan¹, Latonya Carrier¹, David Hangauer^{2, 3} and Brian G. Rowan¹

¹Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA

²Kinex Pharmaceuticals LLC

³State University of New York at Buffalo, Buffalo, New York

25. In Vitro Subcutaneous Absorption of Fenthion using Female Abdominal Skin

Annette M. Hormann

Southern Illinois University-Carbondale, Illinois 62901 USA

26. Interactions of Estrogenic Pesticides on Breast Cancer Cell Gene Expression Evaluated with a Cancer Focused PCR Array System

H. Chris Segar^1,2, Elena V. Skripnikova², Huiming Li², Thomas E. Wiese²

¹Biomedical Sciences Program, Tulane University School of Medicine

²Xavier University of Louisiana College of Pharmacy, New Orleans, LA

27. Sample Preparation of Wastewater and Dissolved Solids for Use in an Estrogen Responsive Cellular Bioassay

Adam B, Streiffer¹, Thomas Wiese², Ponsawat Srisawat³, Deborah Grimm⁴

^1*ERM, 3838 N. Causeway Blvd., STE 2725, Metairie, LA 70002

²Xavier University of Louisiana College of Pharmacy, New Orleans, LA, 70125

³Dept. of Environmental Health, School of Public Health, Tulane University, New Orleans, LA, 70112

⁴Coordinated Instrumentation Facility, Tulane University, New Orleans, LA, 70118

28. A Compilation of Suspected Environmental ED Sites in Louisiana

Rhea Vidrine, Gary LaFleur, Jr.

Biological Sciences, Nicholls State University, Thiobdaux, LA 70310

29. Reproductive Disruption of Fishes by Endocrine-Active Wastewater Effluent

Alan Vajda¹, L.B. Barber², A.B. Bolden³, and D.O. Norris³

¹Department of Integrative Biology, University of Colorado, Denver

²U.S. Geological Survey, Boulder, Colorado

³Department of Integrative Physiology, University of Colorado, Boulder

30. Mechanisms for Inhibition of Crustacean Molting by Organochlorines: an In vitro Approach

Yanling Meng and Enmin Zou

Department of Biological Sciences, Nicholls State University, Thibodaux, LA 70310, USA

31. Alterations of a Biomarker for Molting in the Brown Shrimp, Penaeus aztecus, Subjected to Hypoxia and Sedimentary Naphthalene

Enmin Zou

Department of Biological Sciences, Nicholls State University, Thibodaux, LA 70310, USA

32. Investigation of the Causes of Gonadal Abnormalities in the Chalcalburnus tarichi

Guler Unal¹, Emily Marquez¹, Mara Feld¹, Ahmet R. Oguz², Burak Kaptaner² and Ian P. Callard¹

¹Boston University, Department of Biology, 5 Cummington St., Boston, MA 02215

²Yuzuncu Yil University, Department of Biology, Van 65080-Turkey

33. A Preliminary Study on Immunohisitochemical Detection of Estrogen Receptor in American Alligator Oviducts – Specificity of Antibodies

Ohta, Y.¹, Urushidani, H. ², Takeuchi, T. ¹, Iguchi, T. ², Katsu, Y. ³, Kohno, S. ⁴, Brandon, M. ⁴ and Guillette, L.J. ⁴

¹Department of Veterinary Science, Faculty of Agriculture, Tottori, Japan

²Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, Okazaki, Japan

³Laboratory of Reproductive and Developmental Biology, Graduate School of Life Science, Hokkaido University

⁴Department of Zoology, Florida University, Gainesville, FL, USA

34. Morphological and Molecular Responses in Oviducts of 4 Month-old, FSH-Stimulated Alligators

Brandon C Moore¹, Sara Forouhar², Nicole L. Botteri², Heather J. Hamlin² and Louis. J. Guillette, Jr.²

¹Tulane/Xavier Center for Bioenvironmental Research, New Orleans, Louisiana

²Department of Biology, University of Florida, Gainesville, FL

35. Effects of Embryonic Exposure to Dieldrin and p,p’-DDE on Endocrine Mediated Signaling in the Danio rerio and Trachemys scripta Models

Mara H. Feld¹, Giuseppe Cullaro¹, Emily Marquez¹, Guler Unal³, Pericles Stavropoulos², Ian P. Callard¹

¹Department of Biology, Boston University, Boston MA 02215

²Department of Chemistry, Missouri University of Science and Technology, Rolla MO 65409

³Department of Biology, Yuzunca Yil University, Van Turkey

36. Epithelial Morphology of the American Alligator Phallus

Ketan K. Mathavan, Brandon C. Moore, and Louis J. Guillette, Jr.

Department of Biology, University of Florida, Gainesville, FL

37. Environmental Influence on Yolk Steroids in American Alligators (Alligator mississippiensis)

Hamlin, H.J., Albergotti, L.A., Mutz, J, Guillette, L.J.Jr.

Department of Biology, 223 Bartram Hall, PO Box 118525, University of Florida, Gainesville, Florida, 32611-8525 USA

38. A Novel Approach to the Investigation of Environmental Endocrine Disruptors: Ecotoxicogenomics in the American Alligator (Alligator mississipiensis)

Scott M. Clayman¹, Satomi Kohno¹, Ashley S. P. Boggs¹, Russell H. Lowers² and Louis J. Guillette Jr.¹

¹University of Florida, Department of Biology, Gainesville, FL

²Dynamac Corporation, Kennedy Space Center, FL

39. The Medullary Rest: A Naturally Occurring Intersex Region of American Alligator Ovary

Nicole L. Botteri, Brandon C. Moore, Heather J. Hamlin, Ashley N. Lawler, Ketan Mathavan, and Louis J. Guillette, Jr.

Department of Biology, University of Florida, Gainesville, FL

40. Diagnostic Thyroid Histology of Neonatal American Alligators

Ashley S. P. Boggs¹, Eugenia Timofeev¹, Ketan Mathavan¹, Louis J. Guillette Jr.¹

¹University of Florida, Department of Biology

41. Exploring Steroidogenesis in the Chorioallantoic Membrane of the Domestic Chicken (Gallus gallus) and the American Alligator (Alligator mississippiensis)

Lori C. Albergotti¹, Heather J. Hamlin¹, Michael W. McCoy^1,2, and Louis J. Guillette, Jr.¹

¹Department of Biology, University of Florida, Gainesville, FL,

²Department of Integrative Biology, University of South Florida, Tampa, FL

Wednesday, October 21, 2009

Morning Session
Perspectives (30 years back and 30 years forward)
Chairperson:  Paul Galand

Research Talk I:
Estrogens in the Environment: From the Very Beginning
John A. McLachlan

Research Talk II:
Estrogens and Cell Proliferation: Perspectives
Carlos Sonnenschien

Research Talk III:
Estrogen receptor activities outside the nucleus
Ellis Levin

Research Talk IV:
Disruption of Endocrine System at the Control Level
Andrea Gore

Research Talk V:
Estrogen Receptor Beta and Hormonally Active Chemicals
Jan-Ake Gustafsson

Lunch/Graduate Student Round Table Discussion with Cindy Corbitt and Dana McDowelle

Afternoon Session
Endocrine Mechanisms – Imprinting and Epigenetics
Chairpersons:  David Crews and Melvenia Martin

Research Talk I:
The Role of Epigenetics in Development and Cancer
Shuk-mei Ho

Research Talk II:
Estrogen, Androgen, and Epigenetic Prostate Disease
Gail Prins

Research Talk III:
Epigenetics in Kidney Development in Humans
Samir El Dahr

Research Talk IV:
Transgenerational Effects of Endocrine Disrupting Chemicals
Mike Skinner

e. hormone Poster Session/Reception
Facilitators and Organizers: KiTani Parker-Johnson and Tom Wiese

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Thursday, October 22, 2009

Morning Session
The DES Experience - A Model for Environmental Endocrine Disruption and Transgenerational Disease
Chairpersons: John A. McLachlan and Bich Duong

Research Talk I:
Developmental Exposure to DES
Retha Newbold

Research Talk II:
Gene Imprinting with DES in Rats
Cheryl Walker

Research Talk III:
Recent Results with DES Exposed Humans
Linda Titus-Ermstoff

Research Talk IV:
Epigenetics, Estrogen, and Development
Doug Ruden

Personal Experiences and Speculation in DES Exposure, Lindsey Berkson
Discussion of DES exposure-Lessons Learned, DES Action and audience

Afternoon Session
Endocrine Mechanisms – Signaling and Evolution
Chairpersons:  Chris Williams and Jennifer Fox

Research Talk I:
Evolution of Steroidal Hormonal Response
Michael Baker

Research Talk II:
Evolution of Nuclear Receptors
Joe Thornton

Research Talk III:
Hormonally Active Chemicals Across Various Species
Ann Tarrant

Research Talk IV:
Bisphenol-A: a New Risk Factor for Type II Diabetes
Angel Nadal

Research Talk V:
Androgen and Estrogen Signaling and Gene Regulation
Dan Frigo

Research Talk VI:
Environmental signaling
Charles Miller

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Friday, October 23, 2009

Morning Session
Biologically-Active Agents in the Environment
Chairperson:  John Peterson Myers and Florastina Payton

Research Talk I:
Green Chemistry Approach to Endocrine Disruption
Terry Collins

Research Talk II:
Plant Estrogens and anti-estrogens: the yin and yang of signaling
Matt Burow

Research Talk III:
Bisphenol A and Breast or Reproductive Disease
Ana Soto

Research Talk IV:
Bisphenol A Mechanisms, Activity and Impact
Fred vomSaal

Research Talk V:
Hormonal Responses to Light at Night
David Blask

Afternoon Session
Ecosystem wide effects of environmental signaling
Chairpersons:  Mike Blum and Brandon Moore

Research Talk I:
Biologically Active Chemicals in the Water Stream
Deborah Swackhamer

Research Talk II:
Hydrologic approach to EDC and pharmaceuticals in water
Larry Barber

Research Talk III:
Endocrine Disruption and Development: Sex Determination and Behavior
David Crews

Anniversary Gala

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Saturday, October 24, 2009

Morning Session
Urban and Ecosystem Signaling
Chairpersons:  Bill Toscano and Thea Edwards

Research Talk I:
Biologically active Contaminants in the waste stream
AJ Englande

Research Talk II:
Systems Wide Approach to Endocrine Disruptions
Lou Guillette

Research Talk III:
Endocrine disruption across multiple animal species – common mechanisms?
Taisen Iguchi

Research Talk IV:
Real Life Impacts of Endocrine Disruptions
Tyrone Hayes

Wrap Up/Adjournment

Disclosure Statement

It is the policy of the Center for Continuing Education at Tulane University Health Sciences Center to ensure balance, independence, objectivity and scientific rigor in all its educational programs. All faculty participating in these programs are expected to disclose to the program audiences any real or apparent conflict of interest related to the content of their presentations. This information pertains to relationships with pharmaceutical companies, biomedical device manufacturers or other corporations whose products or services are related to the subject matter of the presentation topic or products in the research and development phase.